Evaluating the therapeutic efficacy of Si-Wu-Tang decoction and concentrated extract in follicular maldevelopment-related menstrual disorders through pharmacokinetic/pharmacodynamic studies.

English | 正體中文 | 简体中文 | 全文笔数/总笔数 : 45422/58598 (78%)
造访人次 : 2547384 在线人数 : 327

RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.

Taipei Medical University Institutional Repository > 教師升等著作 > 教師升等送審著作 > 109 > Item 987654321/65449

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://libir.tmu.edu.tw/handle/987654321/65449

题名:	Evaluating the therapeutic efficacy of Si-Wu-Tang decoction and concentrated extract in follicular maldevelopment-related menstrual disorders through pharmacokinetic/pharmacodynamic studies.
作者:	李佳蓉 Chia-Jung Lee, Alinafe Magret Kapelemera, Yi-Zhe Tsai, Ching-Tzu Lee, Ming-Yi Xu, Ching-Chiung Wang
贡献者:	中草藥臨床藥物研發博士學位學程
关键词:	Keywords: Si-Wu-Tang;ferulic acid;follicular maldevelopment;menstrual disorders;pharmacokinetic/pharmacodynamic
日期:	2020-09
上传时间:	2025-04-02 14:10:38 (UTC+8)
摘要:	Abstract Si-Wu-Tang (SWT), a traditional Chinese formula, is commonly used to relieve menstrual discomfort and climacteric syndrome. Water decoction (WD) and concentrated herbal extract (CHE) are the two most common formulations of traditional Chinese medicine (TCM). However, few studies have reported the equivalency of these two formulations. In this study, 23 healthy volunteers were included to determine the pharmacokinetic (PK) equivalent dosage of WD and CHE, and 25 infertile women with follicular maldevelopment to evaluate the pharmacodynamic (PD) effects on menstrual disorders. The randomized, two-way crossover comparative PK study of SWT-WD and SWT-CHE analyzed the active component, ferulic acid. The results showed that clinical doses of 170 mL SWT-WD and 18 g SWT-CHE produced the same amount of ferulic acid in the blood. The PD study showed that patients who took both of these formulations had an initial luteinizing hormone/follicle-stimulating hormone ratio of <1; however, the value returned to normal and their symptoms all improved after taken SWT. Our results showed that WD and CHE, both prepared from 40 g of SWT, displayed bioequivalence upon PK/PD analysis.
關聯:	Front Pharmacol. 2020 Sep 4; 11: 1245
描述:	【109-2 升等】臺北醫學大學教師升等專門著作職別：專任送審等級：副教授著作送審
数据类型:	article
显示于类别:	[教師升等送審著作] 109

文件中的档案:

档案	描述	大小	格式	浏览次数
index.html		0Kb	HTML	3	检视/开启

在TMUIR中所有的数据项都受到原著作权保护.

TAIR相关文章

著作權聲明 Copyright Notice

本平台之數位內容為臺北醫學大學所收錄之機構典藏，包含體系內各式學術著作及學術產出。秉持開放取用的精神，提供使用者進行資料檢索、下載與取用，惟仍請適度、合理地於合法範圍內使用本平台之內容，以尊重著作權人之權益。商業上之利用，請先取得著作權人之授權。
The digital content on this platform is part of the Taipei Medical University Institutional Repository, featuring various academic works and outputs from the institution. It offers free access to academic research and public education for non-commercial use. Please use the content appropriately and within legal boundaries to respect copyright owners' rights. For commercial use, please obtain prior authorization from the copyright owner.
瀏覽或使用本平台，視同使用者已完全接受並瞭解聲明中所有規範、中華民國相關法規、一切國際網路規定及使用慣例，並不得為任何不法目的使用TMUIR。
By utilising the platform, users are deemed to have fully accepted and understood all the regulations set out in the statement, relevant laws of the Republic of China, all international internet regulations, and usage conventions. Furthermore, users must not use TMUIR for any illegal purposes.
本平台盡力防止侵害著作權人之權益。若發現本平台之數位內容有侵害著作權人權益情事者，煩請權利人通知本平台維護人員([email protected])，將立即採取移除該數位著作等補救措施。
TMUIR is made to protect the interests of copyright owners. If you believe that any material on the website infringes copyright, please contact our staff([email protected]). We will remove the work from the repository.

数据加载中.....