Evaluating the therapeutic efficacy of Si-Wu-Tang decoction and concentrated extract in follicular maldevelopment-related menstrual disorders through pharmacokinetic/pharmacodynamic studies.

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Title:	Evaluating the therapeutic efficacy of Si-Wu-Tang decoction and concentrated extract in follicular maldevelopment-related menstrual disorders through pharmacokinetic/pharmacodynamic studies.
Authors:	李佳蓉 Chia-Jung Lee, Alinafe Magret Kapelemera, Yi-Zhe Tsai, Ching-Tzu Lee, Ming-Yi Xu, Ching-Chiung Wang
Contributors:	中草藥臨床藥物研發博士學位學程
Keywords:	Keywords: Si-Wu-Tang;ferulic acid;follicular maldevelopment;menstrual disorders;pharmacokinetic/pharmacodynamic
Date:	2020-09
Issue Date:	2025-04-02 14:10:38 (UTC+8)
Abstract:	Abstract Si-Wu-Tang (SWT), a traditional Chinese formula, is commonly used to relieve menstrual discomfort and climacteric syndrome. Water decoction (WD) and concentrated herbal extract (CHE) are the two most common formulations of traditional Chinese medicine (TCM). However, few studies have reported the equivalency of these two formulations. In this study, 23 healthy volunteers were included to determine the pharmacokinetic (PK) equivalent dosage of WD and CHE, and 25 infertile women with follicular maldevelopment to evaluate the pharmacodynamic (PD) effects on menstrual disorders. The randomized, two-way crossover comparative PK study of SWT-WD and SWT-CHE analyzed the active component, ferulic acid. The results showed that clinical doses of 170 mL SWT-WD and 18 g SWT-CHE produced the same amount of ferulic acid in the blood. The PD study showed that patients who took both of these formulations had an initial luteinizing hormone/follicle-stimulating hormone ratio of <1; however, the value returned to normal and their symptoms all improved after taken SWT. Our results showed that WD and CHE, both prepared from 40 g of SWT, displayed bioequivalence upon PK/PD analysis.
Relation:	Front Pharmacol. 2020 Sep 4; 11: 1245
Description:	【109-2 升等】臺北醫學大學教師升等專門著作職別：專任送審等級：副教授著作送審
Data Type:	article
Appears in Collections:	[Scholarly output for promotion] 109

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