Structure-solubility relationships among inclusion complexation of hydroxypropyl--cyclodextrin with bicyclic drugs

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Title:	Structure-solubility relationships among inclusion complexation of hydroxypropyl--cyclodextrin with bicyclic drugs
Authors:	胡健民 Hu, Jian-Min
Contributors:	藥學研究所
Keywords:	包覆錯合氫氧丙基--環糊精 5 8-二氫氧基-1 4-酮類衍生物(6+6環) 類衍生物(6+5環) 對位-氫氧基苯甲酸酯纇衍生物藥物學 complexation 5 8-dihydroxy-1 4-naphthoquinone derivatives (6+6 ring structure) indole derivatives (6+5 ring structure) p-hydroxybenzoic acid esters PHARMACOLOGY
Date:	1986
Issue Date:	2009-09-11 16:52:32 (UTC+8)
Abstract:	The complexation of hydroxypropyl--cyclodextrin with bicyclic compounds was studied. 5,8-Dihydroxy-1,4-naphthoquinone derivatives(6+6 ring structure) and indole derivatives (6+5 ring structure) were used as the model chemicals and the solubility increment was employed as an indicator to monitor the complexation progress. The solubility experiments revealed that the position and 3-dimensional structure of the substituents provided more impact on the solubility increment than the polarity and chain length did. This result indicated that both the position and 3-dimensional structure were the major determinants affecting the complexation among the factors studied. The control study with monocyclic compounds, using p- hydroxybenzoic acid esters as the model chemicals, showed opposite results. These results suggested that complexation of hydroxypropyl--cyclodextrin with monocyclic compounds had a different complexation mechanism with the bicyclic compounds.
Data Type:	thesis
Appears in Collections:	[School of Pharmacy] Dissertation/Thesis

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