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    請使用永久網址來引用或連結此文件: http://libir.tmu.edu.tw/handle/987654321/5062


    題名: 銀杏、人參、五味子萃取物複方對四氯化碳誘發肝傷害老鼠肝功能的影響
    Effects of Ginkgo biloba, Panax ginseng, and Schizandra chinensis extract on the functions of damaged liver induced by carbon tetrachlorede
    作者: 張馨方
    Hsin-Fang Chang
    貢獻者: 保健營養學研究所
    關鍵詞: 銀杏
    人參
    五味子
    肝傷害
    Ginkgo biloba
    Panax ginseng
    Schizandra chinensis
    liver damage
    日期: 2005
    上傳時間: 2009-09-10 18:03:02 (UTC+8)
    摘要: 本研究是探討銀杏（Ginkgo biloba）、人參（Panax ginseng）、五味子（Schizandra chinensis）萃取物複方，對CCl4誘發肝傷害老鼠肝功能，抗氧化力及脂質代謝的影響。Sprague-Dawley老鼠以隨機方式分為正常組、CCl4組、CCl4+sliymarin (200 mg/kg/day)組、CCl4+一倍劑量（150 mg/kg/day）組及CCl4+五倍劑量（750 mg/kg/day）組，實驗為期六週。結果顯示，第四週時CCl4組血漿GOT、GPT值顯著高於正常組，CCl4+sliymarin組和CCl4+一倍劑量組之GOT有較CCl4組顯著下降的情形，CCl4+一倍劑量組之GPT值也較CCl4組顯著下降。肝臟抗氧化方面，CCl4組之SOD活性顯著低於正常組，其餘三組與正常組間則無顯著差異，而CCl4+五倍劑量組之catalase活性顯著高於CCl4組，肝臟總抗氧化狀態，CCl4組顯著低於其他四組，CCl4組肝臟中脂質過氧化物MDA含量顯著高於正常組，CCl4+一倍劑量組及CCl4+五倍劑量組則與正常組間無顯著差異，病理切片發現，CCl4+一倍劑量組及CCl4+五倍劑量組肝纖維化有較CCl4組改善。CCl4+一倍劑量組及CCl4+五倍劑量組血漿總膽固醇含量顯著低於CCl4組。由結果推測，此複方可改善因CCl4誘發肝傷害老鼠之肝臟抗氧化能力，並延緩肝纖維化之發生。
    This study investigated the effects of herbal cocktail (Ginkgo biloba, Panax ginseng, and Schizandra chinensis extract) on hepatic functions, antioxidation and lipid metabolism in rats with CCl4-induced liver damage. Sprague-Dawley rats were randomly divided into control, CCl4, CCl4+silymarin(200 mg/kg), CCl4+1herbal extract cocktail(HEC; 150 mg/kg), and CCl4+5HEC(750 mg/kg) groups. The experimental period was 6 weeks. The results showed that the CCl4 group significantly increased plasma GOT and GPT activities at week 4 compared with the control group. However, the 1HEC group significantly decreased plasma GOT and GPT activities at week 4 compared with the CCl4 group. Hepatic SOD activity in the CCl4 group showed significantly lower than that in the control group. The activity of SOD in other three CCl4 groups was not significantly different compared with that in the control group. Hepatic catalase activity in the CCl4+5HEC group showed significantly higher than that in the CCl4 group. The total antioxidant status in the CCl4 group significantly lower than that in other groups. Additionally, hepatic MDA concentration in the CCl4 group was significantly higher than that in the control group. However, MDA concentration in both CCl4+1HEC and CCl4+5HEC groups’ was not significantly different compared with that in the control group. The pathologic results showed that liver fibrosis was ameliorated in the CCl4+1HEC and CCl4+5HEC groups compared with that in the CCl4 group. In addition, both CCl4+1HEC and 5HEC groups significantly decreased plasma total cholesterol compared with the CCl4 group. These results suggest that HEC can improve hepatic antioxidative capacity and decrease liver fibrosis occurring in rats with CCl4-induced liver damage.
    資料類型: thesis
    顯示於類別:[保健營養學系暨研究所] 博碩士論文

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