Necrotizing pneumococcal  pneumonia in children: The role of pulmonary gangrene

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Taipei Medical University Institutional Repository > 臺北醫學大學 • 萬芳醫院 > 內科部 > 期刊論文 > Item 987654321/44497

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題名:	Necrotizing pneumococcal pneumonia in children: The role of pulmonary gangrene
作者:	Yu-Chia Hsieh;Cheng-Hsiang Hsiao;Po-Nien Tsao;Jann-Yuan Wang;Po-Ren Hsueh;Bor-Luen Chiang;Wen-Sen Lee;Li-Min Huang
關鍵詞:	Streptococcus pneumoniae;necrosis;thrombosis;pneumonia.
日期:	2006
上傳時間:	2011-10-11 14:35:59 (UTC+8)
摘要:	Little is known about the mechanism of necrotizing pneumonia caused by Streptococcus pneumoniae in children. Pulmonary gangrene secondary to vascular thrombosis was reported in adults with necrotizing pneumococcal pneumonia.We conducted a retrospective study of 15 children with a diagnosis of necrotizing pneumococcal pneumonia at National Taiwan University Hospital to explore its association with pulmonary gangrene, based on evidence from chest computed tomography, serial chest radiographic patterns, and pathologic results. S. pneumoniae serotype 14 was the prevalent pneumococcal serotype. Overall, 63.6% of isolates were not susceptible to penicillin. One child with pneumonia caused by S. pneumoniae serotype 3 complicated by hemolytic uremic syndrome had a rapidly fatal course. An autopsy in this patient documented lung necrosis and pulmonary gangrene. Radiographic follow-up was performed during the clinical course in 9 patients, and showed no evidence of pulmonary gangrene. Four children had no radiographic follow-up. The relationship between pulmonary gangrene and necrotizing pneumonia was unclear in the remaining one. In conclusion, necrotizing pneumococcal pneumonia may be infrequently associated with pulmonary gangrene in children. Pediatr Pulmonol. 2006; 41:623–629. 2006 Wiley-Liss, Inc.
關聯:	Pediatric Pulmonology 41(7): 623-629.
顯示於類別:	[內科部] 期刊論文

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