Taiwanofungus camphorate activates peroxisome proliferator-activated receptors and induces hypotriglyceride in hypercholesterolemic rats

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題名:	Taiwanofungus camphorate activates peroxisome proliferator-activated receptors and induces hypotriglyceride in hypercholesterolemic rats
作者:	梁有志 Fat-Moon SUK;Shyr-Yi LIN;Chien-Ho CHEN;Shish-Jung YEN;Ching-Hua SU;Der-Zen LIU;Wen-Chi HOU;Ling-Fang HUNG
貢獻者:	醫學檢驗暨生物技術學系
日期:	2008
上傳時間:	2009-08-25 10:39:03 (UTC+8)
摘要:	Taiwanofungus camphoratus (T. camphoratus), a fungus and a Taiwan-specific, well-known traditional Chinese medicine, has long been used to treat diarrhea, hypertension, itchy skin, and liver cancer. To gain a large amount of T. camphoratus, several culture techniques have been developed, including solid-state culture and liquid-state fermentation. Peroxisome proliferator- activated receptor gamma (PPAR) has been described as a hypoglycemic agent that increases insulin sensitivity in peripheral tissues and results in reduced blood glucose, insulin, and triglyceride levels in insulinresistant animals and in type-2 (non-insulin-dependent) diabetic patients. In this study, we investigate the possibility that T. camphoratus might activate PPAR in vitro and hypolipidemic activity in vivo. The results show that an aqueous extract of the wild fruiting bodies of T. camphoratus was able to increase the PPAR activity in cells transfected with the PPAR expression plasmid and the AOx-TK reporter plasmid. Based on the cell experiment, we examined the hypolipidemic effect of wild fruiting bodies (WFT) and a solid-state culture (SST) of T. camphoratus on SD rats fed on a high-cholesterol (HC) diet. The results show that WFT significantly decreased the serum triglyceride level, but could not affect the cholesterol level. SST only slightly decreased the serum triglyceride level. In addition, both WFT and SST significantly decreased the serum alanine transaminase (ALT) level and protected against the liver damage induced by the HC diet from the results of a histological examination. These results suggest that T. camphoratus might contain PPAR ligands and result in a hypotriglyceridemic effect, and that it also exhibits a liver protective activity. Key words: Taiwanofungus camphoratus; peroxisome proliferator-activated receptor; triglyceride; glucose
關聯:	Bioscience,Biotechnology,and Biochemistry.(72):1704-1713.
資料類型:	article
顯示於類別:	[醫學檢驗暨生物技術學系所] 期刊論文

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