Taiwanofungus camphorate activates peroxisome proliferator-activated receptors and induces hypotriglyceride in hypercholesterolemic rats

English | 正體中文 | 简体中文 | Items with full text/Total items : 45422/58598 (78%)
Visitors : 2536149 Online Users : 244

RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.

Home ‧ Login ‧ Upload ‧ Help ‧ About ‧ Administer

TMUIR > College of Medical Science and Technology > > Periodical Articles > Item 987654321/3792

Please use this identifier to cite or link to this item: http://libir.tmu.edu.tw/handle/987654321/3792

Title:	Taiwanofungus camphorate activates peroxisome proliferator-activated receptors and induces hypotriglyceride in hypercholesterolemic rats
Authors:	梁有志 Fat-Moon SUK;Shyr-Yi LIN;Chien-Ho CHEN;Shish-Jung YEN;Ching-Hua SU;Der-Zen LIU;Wen-Chi HOU;Ling-Fang HUNG
Contributors:	醫學檢驗暨生物技術學系
Date:	2008
Issue Date:	2009-08-25 10:39:03 (UTC+8)
Abstract:	Taiwanofungus camphoratus (T. camphoratus), a fungus and a Taiwan-specific, well-known traditional Chinese medicine, has long been used to treat diarrhea, hypertension, itchy skin, and liver cancer. To gain a large amount of T. camphoratus, several culture techniques have been developed, including solid-state culture and liquid-state fermentation. Peroxisome proliferator- activated receptor gamma (PPAR) has been described as a hypoglycemic agent that increases insulin sensitivity in peripheral tissues and results in reduced blood glucose, insulin, and triglyceride levels in insulinresistant animals and in type-2 (non-insulin-dependent) diabetic patients. In this study, we investigate the possibility that T. camphoratus might activate PPAR in vitro and hypolipidemic activity in vivo. The results show that an aqueous extract of the wild fruiting bodies of T. camphoratus was able to increase the PPAR activity in cells transfected with the PPAR expression plasmid and the AOx-TK reporter plasmid. Based on the cell experiment, we examined the hypolipidemic effect of wild fruiting bodies (WFT) and a solid-state culture (SST) of T. camphoratus on SD rats fed on a high-cholesterol (HC) diet. The results show that WFT significantly decreased the serum triglyceride level, but could not affect the cholesterol level. SST only slightly decreased the serum triglyceride level. In addition, both WFT and SST significantly decreased the serum alanine transaminase (ALT) level and protected against the liver damage induced by the HC diet from the results of a histological examination. These results suggest that T. camphoratus might contain PPAR ligands and result in a hypotriglyceridemic effect, and that it also exhibits a liver protective activity. Key words: Taiwanofungus camphoratus; peroxisome proliferator-activated receptor; triglyceride; glucose
Relation:	Bioscience,Biotechnology,and Biochemistry.(72):1704-1713.
Data Type:	article
Appears in Collections:	[ ] Periodical Articles

Files in This Item:

File	Description	Size	Format
91.pdf		171Kb	Adobe PDF	141	View/Open
摘要.pdf		136Kb	Adobe PDF	100	View/Open

著作權聲明 Copyright Notice

本平台之數位內容為臺北醫學大學所收錄之機構典藏，包含體系內各式學術著作及學術產出。秉持開放取用的精神，提供使用者進行資料檢索、下載與取用，惟仍請適度、合理地於合法範圍內使用本平台之內容，以尊重著作權人之權益。商業上之利用，請先取得著作權人之授權。
The digital content on this platform is part of the Taipei Medical University Institutional Repository, featuring various academic works and outputs from the institution. It offers free access to academic research and public education for non-commercial use. Please use the content appropriately and within legal boundaries to respect copyright owners' rights. For commercial use, please obtain prior authorization from the copyright owner.
瀏覽或使用本平台，視同使用者已完全接受並瞭解聲明中所有規範、中華民國相關法規、一切國際網路規定及使用慣例，並不得為任何不法目的使用TMUIR。
By utilising the platform, users are deemed to have fully accepted and understood all the regulations set out in the statement, relevant laws of the Republic of China, all international internet regulations, and usage conventions. Furthermore, users must not use TMUIR for any illegal purposes.
本平台盡力防止侵害著作權人之權益。若發現本平台之數位內容有侵害著作權人權益情事者，煩請權利人通知本平台維護人員([email protected])，將立即採取移除該數位著作等補救措施。
TMUIR is made to protect the interests of copyright owners. If you believe that any material on the website infringes copyright, please contact our staff([email protected]). We will remove the work from the repository.

Loading...