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    請使用永久網址來引用或連結此文件: http://libir.tmu.edu.tw/handle/987654321/1050


    題名: Alterations of serum-derived neurotrophic factor levels in early alcohol withdrawal
    作者: 呂思潔
    Huang MC;Chen CH;Chen CH;Liu SC;Ho CJ;Shen WW;Leu SJ
    貢獻者: 醫學系微生物與免疫學科
    日期: 2008
    上傳時間: 2009-08-14 10:37:38 (UTC+8)
    摘要: Aims: Alcohol withdrawal-enhanced neurotoxicity contributes to the addictive process. Brain-derived neurotrophic factor
    (BDNF) plays an important role in neuronal plasticity and learning. In this study, we explored the changes of serum BDNF levels in
    alcoholic patients at baseline and after one-week alcohol withdrawal. Methods: Twenty-five alcoholic patients were admitted for alcohol
    detoxification treatment, and 22 healthy control subjects were also enrolled. We collected blood samples of the patient group on the
    first and seventh day of alcohol withdrawal, and measured serum BDNF level with sandwich enzyme-linked immunosorbent assay. The
    severity of withdrawal symptoms was evaluated by the Clinical Institute Withdrawal Assessment-Alcohol, Revised every eight hours.
    Results: Serum BDNF levels did not differ significantly between alcoholic patients and control subjects. But BDNF levels were found
    to be significantly increased one week after alcohol withdrawal (from 13.9 ± 3.8 ng/ml to 15.4 ± 3.8 ng/ml, P = 0.03). A significant
    positive correlation was found between baseline BDNF level and baseline withdrawal severity (r = 0.45, P = 0.03). Conclusions: The
    present study suggests that elevated serum BDNF levels were found in early alcohol withdrawal, implying that BDNF may involve in
    neuroadaptation during the period.
    關聯: Alcohol and Alcoholism.
    顯示於類別:[微生物免疫學科] 期刊論文

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