Taipei Medical University Institutional Repository:Item 987654321/9286
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    Please use this identifier to cite or link to this item: http://libir.tmu.edu.tw/handle/987654321/9286


    Title: High Performance Liquid Chromatography Analysis of Tetrahydrozoline Hydrochloride in Ophthalmic Solution by Silica Column Eluted with Aqueous Solvent Mixtures
    Authors: 許明照;何秀娥
    Huang MC;Ho HO;Wen KC;Sheu MT
    Contributors: 藥學系
    Date: 2002
    Issue Date: 2009-10-07 15:16:49 (UTC+8)
    Abstract: A HPLC method using bared silica column eluted with aqueous solvent mobile phase was developed for determination of tetrahydrozoline hydrochloride in ophthalmic preparations. A mixture of methanol and water (70:30, v/v) containing 0.03% triethylamine and 0.02% acetic acid was used as mobile phase, and chlorpheniramine maleate as an internal standard. The flow rate was 1 mL/min and the detection was at 254 nm. The quantitation limit was 1.0 μg/mL. Average recoveries range from 98.9 to 99.9%. The linearity of the calibration curve of tetrahydrozoline hydrochloride was well correlated (r2 = 0.9996) within the range from 12.5 to 500 μg/mL as well as from 1.0 to 20 μg/mL (r2 = 0.9997). This study further reports a simple and quick method for routine quantitative analysis of tetrahydrozoline hydrochloride in an ophthalmic solution that contains a relatively high concentration of sulfamethoxazole sodium and methyl paraben.
    Relation: Journal of Food and Drug Analysis.(10):88-94.
    Data Type: article
    Appears in Collections:[School of Pharmacy] Periodical Article

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    格式.pdf36KbAdobe PDF100View/Open


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