Taipei Medical University Institutional Repository:Item 987654321/892
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    题名: Inappropriate gonadotropin secretion in polycystic ovary syndrome
    作者: 徐明義
    Hsu MI;Liou TH;Liang SJ;Su HW;Wu CH;Hsu CS
    贡献者: 婦產學科
    日期: 2008
    上传时间: 2009-08-13 15:50:54 (UTC+8)
    摘要: Objective
    To evaluate inappropriate gonadotropin secretion in women with polycystic ovary syndrome (PCOS).

    Design
    Retrospective study.

    Setting
    Academic tertiary center.

    Patient(s)
    A total of 373 women were classified into three groups: [1] healthy control women (n = 48); [2] women who were positive for PCOS risk factor; and [3] women with PCOS (n = 251).

    Intervention(s)
    None.

    Main Outcome Measure(s)
    Gonadotropin levels, LH-FSH ratio, body mass index, and clinical and/or biochemical presentations of PCOS.

    Result(s)
    The area under the receiver operating characteristic curve, used to predict PCOS for the LH-FSH ratio, showed similar diagnostic performance to total T and average ovarian volume. The LH-FSH ratio exhibits greater observed accuracy than total T and average ovarian volume for evaluation of women with oligomenorrhea or anovulation. An LH-FSH ratio of >1 presented the best combination of sensitivity and specificity. Body mass index was positively correlated with total T in non-PCOS and PCOS groups; however, body mass index was negatively correlated with LH in PCOS but showed no correlation in non-PCOS subjects.

    Conclusion(s)
    The LH-FSH ratio is a valuable diagnostic tool in evaluating women with PCOS and oligomenorrhea or anovulation, and an LH-FSH ratio of >1 may be used as a decision threshold. The link between body mass index and LH may provide clues for further understanding the pathological milieu of PCOS.
    Relation: Fertility and Sterility
    Data Type: article
    Appears in Collections:[婦產學科] 期刊論文

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