The protective effect of prostacyclin on adriamycin-induced apoptosis in rat renal tubular cells

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題名:	The protective effect of prostacyclin on adriamycin-induced apoptosis in rat renal tubular cells
作者:	陳作孝;蘇裕謀;陳正憲;許永和 Chen CH;Lin H;Hsu YH;Sue YM;Cheng TH;Chan P;Chen TH
貢獻者:	醫學系內科學科
日期:	2006
上傳時間:	2009-10-06 12:34:09 (UTC+8)
摘要:	Adriamycin-induced nephrosis in rats is a commonly used experimental model for pharmacological studies of human chronic renal diseases. Adriamycin-induced apoptosis of renal tubular cells has been reported in adriamycin-treated rats. In addition, prostacyclin (PGI(2)) is known to have various protective effects on many kinds of cells. To investigate the protective effect of PGI(2) on cells undergoing adriamycin-induced apoptosis, this study selectively augmented PGI(2) production via adenovirus-mediated transfer of genes for cyclooxygenase-1 (COX-1) and prostacyclin synthase (PGIS) (two key enzymes of PGI(2) synthesis) to renal tubular cells. This PGI(2) overexpression protected rat renal tubular cells from adriamycin-induced apoptosis. Ad-COX-1/PGIS transfection was found to reduce the adriamycin-stimulated activities of caspase-3 and caspase-9, inhibit adriamycin-induced release of cytochrome c, elevate the expression of Bcl-x(L), and suppress the activation and translocation of nuclear factor-kappaB (NF-kappaB) in adriamycin-treated renal tubular cells. Our results reveal that selective augmentation of PGI(2) production can protect rat renal tubular cells from adriamycin-induced apoptosis via the NF-kappaB signaling pathway. This implies the therapeutic potential of combined COX-1 and PGIS gene transfer in gene therapy for chronic renal diseases.
關聯:	Eur J Pharmacol.(4):8-15.
顯示於類別:	[內科學科] 期刊論文

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