Catcher in the Rel: Nanoparticles-Antibody Conjugate as NF-kB Nuclear Translocation Blocker

English | 正體中文 | 简体中文 | 全文筆數/總筆數 : 45422/58598 (78%)
造訪人次 : 2528944 線上人數 : 183

RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.

Taipei Medical University Institutional Repository > 教師升等著作 > 教師升等送審著作 > 109 > Item 987654321/65501

請使用永久網址來引用或連結此文件: http://libir.tmu.edu.tw/handle/987654321/65501

題名:	Catcher in the Rel: Nanoparticles-Antibody Conjugate as NF-kB Nuclear Translocation Blocker
作者:	陳奕平 Yi-Ping Chen, Chien-Tsu Chen, Tsang-Pai Liu, Fan-Ching Chien, Si-Han Wu, Peilin Chen, Chung-Yuan Mou
貢獻者:	奈米醫學工程研究所
關鍵詞:	Keywords: Antibody therapy;Mesoporous silica nanoparticles;NF-κB;Size hindrance;TAT peptide
日期:	2020-07
上傳時間:	2025-04-02 19:52:23 (UTC+8)
摘要:	Abstract Transcription factor complex NF-κB (p65/p50) is localized to the cytoplasm by its inhibitor IκBα. Upon activation, the Rel proteins p65/p50 are released from IκBα and transported through nuclear pore to affect many gene expressions. While inhibitions of up or down stream signal pathways are often ineffective due to crosstalks and compensations, direct blocking of the Rel proteins p65/p50 has long been proposed as a potential target for cancer therapy. In this work, a nanoparticle/antibody complex targeting NF-κB is employed to catch the Rel protein p65 in perinuclear region and thus blocking the translocation near the nuclear pore gate. TAT peptide conjugated on mesoporous silica nanoparticles (MSN) help non-endocytosis cell-membrane transducing and converge toward perinuclear region, where the p65 specific antibody performed the targeting and catching against active NF-κB p65 effectively. The size of the p65 bound nanoparticle becomes too big to enter nucleus. Simultaneous treatment of mice with the hybrid MSN and doxorubicin conferred a significant therapeutic effect against 4T1 tumor-bearing mice. The new approach of anti-body therapy targeting on transcription factor with "nucleus focusing" and "size exclusion blocking" effects of the antibody-conjugated nanoparticle is general and may be applicable to modulating other transcription factors.
關聯:	Biomaterials. 2020 Jul; 246: 119997
描述:	【109-1 升等】臺北醫學大學教師升等專門著作職別：專任送審等級：副教授著作送審
資料類型:	article
顯示於類別:	[教師升等送審著作] 109

文件中的檔案:

檔案	描述	大小	格式	瀏覽次數
index.html		0Kb	HTML	5	檢視/開啟

在TMUIR中所有的資料項目都受到原著作權保護.

TAIR相關文章

著作權聲明 Copyright Notice

本平台之數位內容為臺北醫學大學所收錄之機構典藏，包含體系內各式學術著作及學術產出。秉持開放取用的精神，提供使用者進行資料檢索、下載與取用，惟仍請適度、合理地於合法範圍內使用本平台之內容，以尊重著作權人之權益。商業上之利用，請先取得著作權人之授權。
The digital content on this platform is part of the Taipei Medical University Institutional Repository, featuring various academic works and outputs from the institution. It offers free access to academic research and public education for non-commercial use. Please use the content appropriately and within legal boundaries to respect copyright owners' rights. For commercial use, please obtain prior authorization from the copyright owner.
瀏覽或使用本平台，視同使用者已完全接受並瞭解聲明中所有規範、中華民國相關法規、一切國際網路規定及使用慣例，並不得為任何不法目的使用TMUIR。
By utilising the platform, users are deemed to have fully accepted and understood all the regulations set out in the statement, relevant laws of the Republic of China, all international internet regulations, and usage conventions. Furthermore, users must not use TMUIR for any illegal purposes.
本平台盡力防止侵害著作權人之權益。若發現本平台之數位內容有侵害著作權人權益情事者，煩請權利人通知本平台維護人員([email protected])，將立即採取移除該數位著作等補救措施。
TMUIR is made to protect the interests of copyright owners. If you believe that any material on the website infringes copyright, please contact our staff([email protected]). We will remove the work from the repository.

資料載入中.....