Reduced tract integrity of the model for social communication is a neural substrate of social communication deficits in autism spectrum disorder.

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題名:	Reduced tract integrity of the model for social communication is a neural substrate of social communication deficits in autism spectrum disorder.
作者:	羅伃君 Yu-Chun Lo, Yu-Jen Chen, Yung-Chin Hsu, Wen-Yih Isaac Tseng, Susan Shur-Fen Gau
貢獻者:	神經再生醫學博士學位學程
關鍵詞:	Keywords: Autism spectrum disorders;brain imaging;communication
日期:	2017-05
上傳時間:	2025-04-02 19:24:05 (UTC+8)
摘要:	Abstract Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with social communication deficits as one of the core symptoms. Recently, a five-level model for the social communication has been proposed in which white matter tracts corresponding to each level of the model are identified. Given that the model for social communication subserves social language functions, we hypothesized that the tract integrity of the model for social communication may be reduced in ASD, and the reduction may be related to social communication deficits. Methods: Sixty-two right-handed boys with ASD and 55 typically developing (TD) boys received clinical evaluations, intelligence tests, the Social Communication Questionnaire (SCQ), and MRI scans. Generalized fractional anisotropy (GFA) was measured by diffusion spectrum imaging to indicate the microstructural integrity of the tracts for each level of the social communication model. Group difference in the tract integrity and its relationship with the SCQ subscales of social communication and social interaction were investigated. Results: We found that the GFA values of the superior longitudinal fasciculus III (SLF III, level 1) and the frontal aslant tracts (FAT, level 2) were decreased in ASD compared to TD. Moreover, the GFA values of the SLF III and the FAT were associated with the social interaction subscale in ASD. Conclusions: The tract integrity of the model for social communication is reduced in ASD, and the reduction is associated with impaired social interaction. Our results support that reduced tract integrity of the model for social communication might be a neural substrate of social communication deficits in ASD.
關聯:	J Child Psychol Psychiatry. 2017 May; 58(5): 576-585
描述:	【109-1 升等】臺北醫學大學教師升等專門著作職別：專任送審等級：副教授著作送審
資料類型:	article
顯示於類別:	[教師升等送審著作] 109

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