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    題名: Combined Effects of MMP-7, MMP-8 and MMP-26 on the Risk of Ischemic Stroke
    作者: 連立明
    Fang-I Hsieh, Hung-Yi Chiou, Chaur-Jong Hu, Jiann-Shing Jeng, Huey-Juan Lin, Jiunn-Tay Lee, Li-Ming Lien
    貢獻者: 醫學系神經學科
    關鍵詞: Keywords: MMP-26;MMP-7;MMP-8;ischemic stroke;weighted genetic risk score
    日期: 2019-11
    上傳時間: 2025-04-02 17:40:47 (UTC+8)
    摘要: Abstract
    Ischemic stroke (IS) is multifactorial causation combining with traditional cardiovascular disease (CVD) and genetic risk factors. Combined effects of MMP-7, MMP-8 and MMP-26 on the risk of IS remain incompletely understood. We aimed to assess individual and joint effects for IS risk by weighted genetic risk score (wGRS) from these three genes and traditional CVD risk factors. A case-control study including 500 cases with IS and 500 stroke-free healthy controls frequency-matched with cases by age and sex was conducted. The wGRS was a weighted average of the number of risk genotype across selected SNPs from MMP-7, MMP-8 and MMP-26. Multivariate logistic regression models were used to analyze the relationship between wGRS and risk of IS. A wGRS in the second tertile was associated with a 1.5-fold increased risk of IS compared with the lowest tertile after adjusting for traditional CVD risk factors. Compared to subjects with low genetic and low modifiable CVD risk, those with high genetic and high modifiable CVD risk had the highest risk of IS (adjusted-OR = 5.75). In conclusion, higher wGRS was significantly associated with an increased risk for IS. A significant interaction between genetic and traditional CVD risk factors was also found on the risk of IS.
    關聯: J Clin Med. 2019 Nov 18; 8(11): 2011
    描述: 【109-1 升等】臺北醫學大學教師升等專門著作
    職別:專任
    送審等級:教授
    著作送審
    資料類型: article
    顯示於類別:[教師升等送審著作] 109

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