Investigation into the pulmonary inflammopathology of exposure to nickel oxide nanoparticles in mice

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Title:	Investigation into the pulmonary inflammopathology of exposure to nickel oxide nanoparticles in mice
Authors:	莊校奇 Kuan-Jen Bai, Kai-Jen Chuang, Jen-Kun Chen, His-En Hua, Yen-Ling Shen, Wei-Neng Liao, Chii-Hong Lee, Kuan-Yuan Chen, Kang-Yun Lee, Ta-Chih Hsiao, Chih-Hong Pan, Kin-Fai Ho, Hsiao-Chi Chuang
Contributors:	呼吸治療學系
Date:	2018-10
Issue Date:	2025-04-02 16:43:01 (UTC+8)
Abstract:	Abstract We investigated the effects of nickel oxide nanoparticles (NiONPs) on the pulmonary inflammopathology. NiONPs were intratracheally installed into mice, and lung injury and inflammation were evaluated between 1 and 28 days. NiONPs caused significant increases in LDH, total protein, and IL-6 and a decrease in IL-10 in the BALF and increases in 8-OHdG and caspase-3 in lung tissues at 24 h. Airway inflammation was present in a dose-dependent manner from the upper to lower airways at 24 h of exposure as analyzed by SPECT. Lung parenchyma inflammation and small airway inflammation were observed by CT after NiONP exposure. 8-OHdG in lung tissues had increased with formation of fibrosis at 28 days. Focal adhesion was the most important pathways identified at 24 h as determined by protemics, whereas glutathione metabolism was the most important identified at 28 days. Our results demonstrated the pulmonary inflammopathology caused by NiONPs based on image-to-biochemical approaches.
Relation:	Nanomedicine. 2018 Oct; 14(7): 2329-2339
Description:	【109-1 升等】臺北醫學大學教師升等專門著作職別：專任送審等級：教授著作送審
Data Type:	article
Appears in Collections:	[Scholarly output for promotion] 109

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