miR-103/107 prolong Wnt/β-catenin signaling and colorectal cancer stemness by targeting Axin2.

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题名:	miR-103/107 prolong Wnt/β-catenin signaling and colorectal cancer stemness by targeting Axin2.
作者:	陳忻怡 Hsin-Yi Chen, Yaw-Dong Lang, Han-Nan Lin, Yun-Ru Liu, Chun-Chieh Liao, Andr? Wendindond? Nana, Yun Yen & Ruey-Hwa Chen
贡献者:	癌症生物學與藥物研發研究所
日期:	2019-07
上传时间:	2025-04-02 15:03:42 (UTC+8)
摘要:	Abstract Cancer stemness drives tumor initiation, progression, metastasis, recurrence, and therapy resistance. However, mechanisms that potentiate the acquisition and maintenance of stemness fate of cancer cells remain incompletely understood. Here, we show that miR-103/107 stimulate multiple stem-like features in colorectal cancer, including expression of stem-like markers, appearance of side-population cells, and capabilities in self-renewal, tumor initiation, recurrence, and chemoresistance. Mechanistically, these stemness-promoting functions are mediated by miR-103/107-dependent repression of Axin2, a negative feedback regulator of Wnt/β-catenin signaling. Through inhibiting Axin2, miR-103/107 trigger a prolonged duration of Wnt/β-catenin signaling and a sustained induction of Wnt responsive genes. In colorectal cancer patients, miR-103/107 expression correlates inversely with Axin2 expression and a signature of miR-103/107 high and Axin2 low expression profile correlates with poor prognosis. Together, our study identifies a novel function of miR-103/107 in promoting colorectal cancer stemness by targeting Axin2 and elucidates the clinical relevance and prognostic value of this axis in colorectal cancer.
關聯:	Scientific Reports volume 9, Article number: 9687 (2019)
描述:	【109-2 升等】臺北醫學大學教師升等專門著作職別：專任送審等級：副教授著作送審
数据类型:	article
显示于类别:	[教師升等送審著作] 109

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