Incidence and risk factors of sudden cardiac death in bipolar disorder across the lifespan

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題名:	Incidence and risk factors of sudden cardiac death in bipolar disorder across the lifespan
作者:	陳抱寰 Pao-Huan Chen, Shang-Ying Tsai, Chun-Hung Pan, Hu-Ming Chang, Yi-Lung Chen, Sheng-Siang Su, Chiao-Chicy Chen, Chian-Jue Kuo
貢獻者:	醫學系精神學科
關鍵詞:	Keywords: Bipolar disorder;Sudden cardiac death;Incidence;Standardized mortality ratio;Risk factor;Age effect
日期:	2020-09
上傳時間:	2025-04-01 21:05:18 (UTC+8)
摘要:	Abstract: Objective Data on the incidence and risk factors of sudden cardiac death in patients with bipolar disorder are lacking in the literature. Methods By using data from the Taiwan National Health Insurance Research Database and Department of Health Death Certification System between 2000 and 2016, we conducted a prospective national cohort study to determine the incidence and risk factors of sudden cardiac death in bipolar disorder patients. The study cohort included 46,490 patients with bipolar disorder, 467 of whom experienced sudden cardiac death. Results Stratified analyses showed that the standardized mortality ratios (SMRs) of sudden cardiac death were all above 1.00 across each age interval, with the highest SMR in patients aged <30 years (31.96, 95% CI: 20.47–47.55). Notably, hypertension raised the risk of sudden cardiac death in both patients aged <50 years (1.85, 95% CI: 1.23–2.79) and aged ?50 years (1.44, 95% CI: 1.14–1.83). In addition, venous and lymphatic disorders (1.97, 95% CI: 1.23–3.16), and alcohol use-related disorder (2.34, 95% CI: 1.62–3.38) elevated the risk of sudden cardiac death in patients aged <50 years. Congestive heart failure (1.59, 95% CI: 1.13–2.23) and dementia (1.75, 95% CI: 1.30–2.35) increased the risk of sudden cardiac death in patients aged ?50 years. Conclusions The risk of sudden cardiac death is remarkably high in bipolar disorder patients across the lifespan. Prevention strategies specific to individuals with bipolar disorder are urgently required.
關聯:	Journal of Affective Disorders, Volume 274, 2020, Pages 210-217
描述:	【109-2 升等】臺北醫學大學教師升等專門著作職別：專任送審等級：助理教授著作送審
資料類型:	article
顯示於類別:	[教師升等送審著作] 109

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