Hydrolyzed Chicken Extract (ProBeptigen?) on Cognitive Function in Healthy Middle-Aged People: A Randomized Double-Blind Trial.

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Title:	Hydrolyzed Chicken Extract (ProBeptigen?) on Cognitive Function in Healthy Middle-Aged People: A Randomized Double-Blind Trial.
Authors:	鄔定宇 Dean Wu, Cheng-Chang Yang, Kuan-Yu Chen, Ying-Chin Lin, Pei-Jung Wu, Pei-Hsiu Hsieh, Yoshihiro Nakao, Mandy Y L Ow, Yi-Chen Hsieh, Chaur-Jong Hu
Contributors:	醫學系神經學科
Date:	2020-05
Issue Date:	2025-04-01 21:05:17 (UTC+8)
Abstract:	Abstract Cognitive decline is an important issue of global public health. Cognitive aging might begin at middle adulthood, the period particularly vulnerable to stress in lifespan. Essence of chicken (EOC) has consistently demonstrated its beneficial effects on various cognitive domains as nutritional supplementation. This study primarily aimed to examine the cognitive enhancement effects of ProBeptigen? (previously named CMI-168), hydrolyzed peptides extracted from EOC, in healthy middle-aged people under mild stress. Ninety healthy subjects were randomly assigned into the ProBeptigen? or placebo group for eight weeks. Neurocognitive assessment, event-related potentials (ERPs), and blood tests were conducted before, during, and after the treatment. The ProBeptigen? group outperformed placebo group on Logical Memory subtests of Wechsler Memory Scale-third edition (WMS-III) and Spatial Working Memory task in the Cambridge Neuropsychological Test Automated Battery (CANTAB). The anti-inflammatory effects of ProBeptigen? in humans were also confirmed, with progressively declining high-sensitivity C-reactive protein (hs-CRP) levels. Regular dietary supplementation of ProBeptigen? is suggested to improve verbal short- and long-term memory as well as spatial working memory, and reduce inflammation in middle-aged healthy individuals with stress. The effects of ProBeptigen? on cognition warrant further investigation. (NCT03612752).
Relation:	Nutrients. 2020 May 10; 12(5): 1362
Description:	【109-2 升等】臺北醫學大學教師升等專門著作職別：專任送審等級：副教授著作送審
Data Type:	article
Appears in Collections:	[Scholarly output for promotion] 109

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