資料載入中.....
|
請使用永久網址來引用或連結此文件:
http://libir.tmu.edu.tw/handle/987654321/65431
|
| 題名: | Iron and Advanced Glycation End Products: Iron's Emerging Role in Androgen Deficiency in Obesity |
| 作者: | 陳淑華
Seu-Hwa Chen, Kuo-Ching Yuan, Yu-Chieh Lee, Chun-Kuang Shih, Sung-Hui Tseng, Alexey A Tinkov, Anatoly V Skalny, Jung-Su Chang |
| 貢獻者: | 醫學系解剖學暨細胞生物學科 |
| 日期: | 2020-03 |
| 上傳時間: | 2025-04-01 20:11:51 (UTC+8) |
| 摘要: | Abstract
The literature suggests a bidirectional relationship between testosterone (T) and iron, but mechanisms underlying this relationship remain unclear. We investigated effects of iron on advanced glycation end products (AGEs) in obesity-related androgen deficiency. In total, 111 men were recruited, and iron biomarkers and N(?)-(carboxymethyl)lysine (CML) were measured. In an animal study, rats were fed a 50% high-fat diet (HFD) with (0.25, 1, and 2 g ferric iron/kg diet) or without ferric citrate for 12 weeks. Obese rats supplemented with >1 g iron/kg diet had decreased testicular total T compared to HFD alone. Immunohistochemical staining showed that >1 g of ferric iron increased iron and AGE retention in testicular interstitial tissues, which is associated with increased expression of the receptor for AGEs (RAGE), tumor necrosis factor-α, and nitric oxide. Compared with normal weight, overweight/obese men had lower T levels and higher rates of hypogonadism (19% vs. 11.3%) and iron overload (29.8% vs.15.9%). A correlation analysis showed serum total T was positively correlated with transferrin saturation (r = 0.242, p = 0.007) and cathepsin D (r = 0.330, p = 0.001), but negatively correlated with red blood cell aggregation (r = -0.419, p<0.0001) and CML (r = -0.209, p < 0.05). In conclusion, AGEs may partially explain the underlying relationship between dysregulated iron and T deficiency. |
| 關聯: | Antioxidants (Basel). 2020 Mar 22; 9(3): 261 |
| 描述: | 【109-2 升等】臺北醫學大學教師升等專門著作
職別：專任
送審等級：副教授
著作送審 |
| 資料類型: | article |
| 顯示於類別: | [教師升等送審著作] 109
|
文件中的檔案:
| 檔案 |
描述 |
大小 | 格式 | 瀏覽次數 |
|---|
| index.html | | 0Kb | HTML | 1 | 檢視/開啟 |
|
在TMUIR中所有的資料項目都受到原著作權保護.
|
