Molecular epidemiology and characterization of carbapenem-resistant Klebsiella pneumoniae isolated from urine at a teaching hospital in Taiwan

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Title:	Molecular epidemiology and characterization of carbapenem-resistant Klebsiella pneumoniae isolated from urine at a teaching hospital in Taiwan
Authors:	黃姿雯 Yuarn-Jang Lee, Chih-Hung Huang, Noor Andryan Ilsan, I-Hui Lee, Tzu-Wen Huang
Contributors:	醫學系微生物免疫學科
Keywords:	Keywords: antimicrobial resistance;carbapenem-resistant mechanism;carbapenemase;extended-spectrum β-lactamase;urinary tract infection
Date:	2021-01
Issue Date:	2025-04-01 16:53:41 (UTC+8)
Abstract:	Abstract Urinary tract infections (UTIs) are common in clinics and hospitals and are associated with a high economic burden. Enterobacterium Klebsiella pneumoniae is a prevalent agent causing UTIs. A high prevalence of carbapenem-resistant K. pneumoniae (CRKP) has emerged recently and is continuing to increase. Seventeen urinary CRKP isolates collected at a teaching hospital in Taiwan from December 2016 to September 2017 were analyzed to elucidate their drug resistance mechanisms. Two-thirds of the isolates were obtained from outpatients. Antimicrobial susceptibility tests demonstrated multidrug resistance in all the isolates. Multilocus sequence typing analysis showed high diversity among the isolates. PCR analysis demonstrated the presence of carbapenemases in three isolates. All isolates carried at least one other extended-spectrum β-lactamase, including TEM, DHA, and CTX-M. Fifteen isolates contained mutations in one of the outer membrane porins that were assessed. The expression levels of the acrB and/or oqxB efflux pump genes, as determined by qRT-PCR, were upregulated in 11 isolates. Six isolates might have utilized other efflux pumps or antimicrobial resistance mechanisms. These analyses demonstrated a highly diverse population and the presence of complex resistance mechanisms in urinary isolates of K. pneumoniae.
Relation:	Microorganisms. 2021 Jan 28; 9(2): 271
Description:	【110-1 升等】臺北醫學大學教師升等專門著作職別：專任送審等級：副教授著作送審
Data Type:	article
Appears in Collections:	[Scholarly output for promotion] 110

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