Hyperglycemia-related FAS gene and hsa-let-7b-5p as markers of poor outcomes for ischemic stroke

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題名:	Hyperglycemia-related FAS gene and hsa-let-7b-5p as markers of poor outcomes for ischemic stroke
作者:	謝宜蓁 Nai-Fang Chi, Hung-Yi Chiou, Szu-Yi Chou, Chaur-Jong Hu, Kai-Yun Chen, Cheng-Fu Chang, Yi-Chen Hsieh
貢獻者:	神經再生醫學博士學位學程
日期:	2020-08
上傳時間:	2025-03-31 16:36:24 (UTC+8)
摘要:	Abstract Background and purpose: Hyperglycemia in acute stroke leads to poor neurological outcomes. The role of microRNA (miRNA) in hyperglycemia-associated genes can provide new avenues for stroke prognostic applications. We aimed to identify novel genes and their regulated miRNAs that are associated with hyperglycemia-induced unfavorable stroke outcomes and further validated in the plasma exosome. Moreover, we intended to evaluate the prognostic ability of miRNA-messenger RNA (mRNA) biomarkers in addition to using traditional risk factors. Methods: After the integration analysis of small RNA sequencing and mRNA polymerase chain reaction array, two mRNAs and six miRNAs were selected for validation in middle cerebral artery occlusion animal models and ischaemic stroke patients. Receiver operator characteristic analysis was used to determine the performance of mRNA and miRNA expression. Results: The increased Fas expression was associated with hyperglycemia after acute stroke onset in animal and human studies. In addition, Fas gene level was significantly higher in patients with an unfavorable outcome when compared with patients with a favorable outcome. The expression of Fas and miRNA hsa-let-7b-5p in addition to traditional risk factors could increase the discrimination and predictive ability for poor prognosis. The higher exosomal Fas was further observed among patients with an unfavorable outcome, suggesting Fas signal transporting through exosome in the circulation system. Conclusions: Combined analyses of Fas and has-let-7b-5p expression in addition to traditional risk factors are favorable prognostic biomarkers for predicting poor neurological outcomes at 3 months after stroke onset in ischaemic stroke patients. Additional studies are required to address the precise role of the apoptosis pathway in unfavorable hyperglycemia-induced stroke outcomes.
關聯:	Eur J Neurol. 2020 Aug; 27(8): 1647-1655
描述:	【110-2 升等】臺北醫學大學教師升等專門著作職別：專任送審等級：教授著作送審
資料類型:	article
顯示於類別:	[教師升等送審著作] 110

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