Biocompatibility and biological performance evaluation of additive-manufactured bioabsorbable iron-based porous suture anchor in a rabbit model.

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Title:	Biocompatibility and biological performance evaluation of additive-manufactured bioabsorbable iron-based porous suture anchor in a rabbit model.
Authors:	陳致宇 Chien-Cheng Tai, Hon-Lok Lo, Chen-Kun Liaw, Yu-Min Huang, Yen-Hua Huang, Kuo-Yi Yang, Chih-Chieh Huang, Shin-I Huang, Hsin-Hsin Shen, Tzu-Hung Lin, Chun-Kuan Lu, Wen-Chih Liu, Jui-Sheng Sun, Pei-I Tsai, Chih-Yu Chen
Contributors:	國際生醫工程博士學位學程
Date:	2021-07
Issue Date:	2025-03-31 11:45:00 (UTC+8)
Abstract:	Abstract This study evaluated the biocompatibility and biological performance of novel additive-manufactured bioabsorbable iron-based porous suture anchors (iron_SAs). Two types of bioabsorbable iron_SAs, with double- and triple-helical structures (iron_SA_2_helix and iron_SA_3_helix, respectively), were compared with the synthetic polymer-based bioabsorbable suture anchor (polymer_SAs). An in vitro mechanical test, MTT assay, and scanning electron microscope (SEM) analysis were performed. An in vivo animal study was also performed. The three types of suture anchors were randomly implanted in the outer cortex of the lateral femoral condyle. The ultimate in vitro pullout strength of the iron_SA_3_helix group was significantly higher than the iron_SA_2_helix and polymer_SA groups. The MTT assay findings demonstrated no significant cytotoxicity, and the SEM analysis showed cells attachment on implant surface. The ultimate failure load of the iron_SA_3_helix group was significantly higher than that of the polymer_SA group. The micro-CT analysis indicated the iron_SA_3_helix group showed a higher bone volume fraction (BV/TV) after surgery. Moreover, both iron SAs underwent degradation with time. Iron_SAs with triple-helical threads and a porous structure demonstrated better mechanical strength and high biocompatibility after short-term implantation. The combined advantages of the mechanical superiority of the iron metal and the possibility of absorption after implantation make the iron_SA a suitable candidate for further development.
Relation:	Int J Mol Sci. 2021 Jul 8; 22(14): 7368
Description:	【111-1 升等】臺北醫學大學教師升等專門著作職別：專任送審等級：副教授著作送審
Data Type:	article
Appears in Collections:	[Scholarly output for promotion] 111

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