Porous scaffold for mesenchymal cell encapsulation and exosome-based therapy of ischemic diseases

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Taipei Medical University Institutional Repository > 教師升等著作 > 教師升等送審著作 > 111 > Item 987654321/65289

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Title:	Porous scaffold for mesenchymal cell encapsulation and exosome-based therapy of ischemic diseases
Authors:	David Jon Lundy Andreas Czosseck, Max M. Chen, Helen Nguyen, Annette Meeson, Chuan-Chih Hsu, Chien-Chung Chen, Thomashire A. George, Shu-Chian Ruan, Yuan-Yuan Cheng, Po-Ju Lin, Patrick C.H. Hsieh, David J. Lundy
Contributors:	生醫材料暨組織工程研究所
Keywords:	Keywords: Myocardial infarction;Limb ischemia;Extracellular vesicle;Cell encapsulation;Cell therapy;Exosome;Ischemic disease;Cardiac patch
Date:	2022-12
Issue Date:	2025-03-30 20:53:26 (UTC+8)
Abstract:	Abstract: Ischemic diseases including myocardial infarction (MI) and limb ischemia are some of the greatest causes of morbidity and mortality worldwide. Cell therapy is a potential treatment but is usually limited by poor survival and retention of donor cells injected at the target site. Since much of the therapeutic effects occur via cell-secreted paracrine factors, including extracellular vesicles (EVs), we developed a porous material for cell encapsulation which would improve donor cell retention and survival, while allowing EV secretion. Human donor cardiac mesenchymal cells were used as a model therapeutic cell and the encapsulation system could sustain three-dimensional cell growth and secretion of therapeutic factors. Secretion of EVs and protective growth factors were increased by encapsulation, and secreted EVs had hypoxia-protective, pro-angiogenic activities in in vitro assays. In a mouse model of limb ischemia the implant improved angiogenesis and blood flow, and in an MI model the system preserved ejection fraction %. In both instances, the encapsulation system greatly extended donor cell retention and survival compared to directly injected cells. This system represents a promising therapy for ischemic diseases and could be adapted for treatment of other diseases in the future.
Relation:	Journal of Controlled Release, Volume 352, 2022, Pages 879-892
Description:	【111-2 升等】臺北醫學大學教師升等專門著作職別：專任教師送審等級：副教授著作送審
Data Type:	article
Appears in Collections:	[教師升等送審著作] 111

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