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| 題名: | Atypical Teratoid/Rhabdoid Tumor in Taiwan: A Nationwide, Population-Based Study |
| 作者: | 劉彥麟
Yen Lin Liu, ?Min Lan Tsai,?Chang I. Chen, Noi Yar, Ching Wen Tsai,?Hsin Lun Lee,?Chia Chun Kuo,?Wan Ling Ho,?Kevin Li Chun Hsieh,?Sung Hui Tseng, James S. Miser,?Chia Yau Chang,?Hsi Chang, Wen Chang Huang,?Tai Tong Wong,?Alexander T.H. Wu, Yu Chun Yen |
| 貢獻者: | 醫學系小兒學科 |
| 關鍵詞: | Keywords: CNS tumors;atypical teratoid/rhabdoid tumor;pediatric cancer;survival outcome |
| 日期: | 2022-01 |
| 上傳時間: | 2025-03-30 16:29:59 (UTC+8) |
| 摘要: | Abstract
Background: Atypical teratoid/rhabdoid tumor (AT/RT) is a rare, highly aggressive embryonal brain tumor most commonly presenting in young children.
Methods: We performed a nationwide, population-based study of AT/RT (ICD-O-3 code: 9508/3) in Taiwan using the Taiwan Cancer Registry Database and the National Death Certificate Database.
Results: A total of 47 cases (male/female = 29:18; median age at diagnosis, 23.3 months (IQR: 12.5-87.9)) were diagnosed with AT/RT between 1999 and 2014. AT/RT had higher prevalence in males (61.70%), in children < 36 months (55.32%), and at infratentorial or spinal locations (46.81%). Survival analyses demonstrated that patients ? 3 years of age (n = 21 (45%)) had a 5y-OS of 41% (p < 0.0001), treatment with radiotherapy only (n = 5 (11%)) led to a 5y-OS of 60%, treatment with chemotherapy with or without radiotherapy (n = 27 (62%)) was associated with a 5y-OS of 45% (p < 0.0001), and patients with a supratentorial tumor (n = 11 (23%)) had a 5y-OS of 51.95%. Predictors of better survival on univariate Cox proportional hazard modeling and confirmed with multivariate analysis included older age (?1 year), supratentorial sites, and the administration of radiotherapy, chemotherapy, or both. Gender had no effect on survival.
Conclusion: Older age, supratentorial site, and treatment with radiotherapy, chemotherapy, or both significantly improves the survival of patients with AT/RT. |
| 關聯: | Cancers (Basel). 2022 Jan 28;14(3):668 |
| 描述: | 【111-2 升等】臺北醫學大學教師升等專門著作
職別：專任教師
送審等級：副教授
著作送審 |
| 資料類型: | article |
| 顯示於類別: | [教師升等送審著作] 111
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