Prognostic value of localization of epidermal growth factor receptor in lung adenocarcinoma

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Title:	Prognostic value of localization of epidermal growth factor receptor in lung adenocarcinoma
Authors:	王錦莉 Jinn-Li Wang, Chia-Lang Fang, Yu-Tien Tzeng, Han-Lin Hsu, Sey-En Lin, Ming-Chih Yu, Kuan-Jen Bai, Liang-Shun Wang, Hsingjin Eugene Liu
Contributors:	醫學系小兒學科
Keywords:	Keywords:?Epidermal growth factor receptor;Immunohistochemistry;Localization;Lung adenocarcinoma;Survival
Date:	2018-06
Issue Date:	2025-03-30 16:29:57 (UTC+8)
Abstract:	Abstract Background: The nuclear translocation of epidermal growth factor receptor (EGFR) has been considered to play a role in carcinogenesis. However, the relevance of differentially located EGFR proteins in lung cancer remains unclear. Methods: We examined 161 patients with primary lung adenocarcinoma to detect EGFR expression in lung cancer cells using immunohistochemistry and determined the correlations of EGFR expression with clinical characteristics, EGFR mutations, and survival time. Moreover, we graded complete membranous staining with strong intensity as high membranous EGFR (mEGFR) expression, and nuclear EGFR staining with strong intensity as high nuclear (nEGFR) expression. Results: The prevalence of high mEGFR and nEGFR expression in lung adenocarcinoma was 42.86 and 39.13%, respectively. After multivariate analyses, high mEGFR expression was associated with a significantly reduced mortality risk in older patients, those with a history of smoking, and those without brain metastasis (hazard ratio[95% confidential interval], HR[95% CI] = 0.55[0.32~ 0.92]; 0.51[0.26~ 0.98] and 0.56[0.33~ 0.94], in overall survival, respectively). An association between high nEGFR expression and early recurrence was observed in patients with metastasis (HR[95% CI] =1.68[1.05~ 2.68], in progression-free survival). Notably, patients with low mEGFR and low nEGFR expression had the lowest survival rate in cases without brain metastasis (p = 0.018) and with a history of smoking (p = 0.062) and total EGFR (any high mEGFR or nEGFR) expression indicated a more favorable response to platinum-based chemotherapy regardless of EGFR mutations (HR[95% CI] =0.33[0.12-0.92]; adjusted HR[95% CI] = 0.36[0.13~ 1.02] with the use of tyrosine kinase inhibitor). Conclusions: EGFR proteins at different cellular locations in lung adenocarcinoma might influence the biology of cancer cells and are an independent indicator of more favorable prognosis and treatment response.
Relation:	J Biomed Sci. 2018 Jun 28;25(1):53
Description:	【111-2 升等】臺北醫學大學教師升等專門著作職別：專任教師送審等級：副教授著作送審
Data Type:	article
Appears in Collections:	[Scholarly output for promotion] 111

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