 |
English
|
正體中文
|
简体中文
|
全文筆數/總筆數 : 45422/58598 (78%)
造訪人次 : 2543931
線上人數 : 213
|
|
|
資料載入中.....
|
請使用永久網址來引用或連結此文件:
http://libir.tmu.edu.tw/handle/987654321/65264
|
| 題名: | Aminoglycosides use has a risk of acute kidney injury in patients without prior chronic kidney disease. |
| 作者: | 鄒居霖
Chu Lin Chou, Nai Chen Chuang, Hui Wen Chiu, Chia Te Liao, Yung Ho Hsu, Tzu Hao Chang |
| 貢獻者: | 醫學系內科學科腎臟內科 |
| 日期: | 2022-10 |
| 上傳時間: | 2025-03-30 16:03:19 (UTC+8) |
| 摘要: | Abstract
The outcome of acute kidney injury (AKI) as a result of aminoglycosides (AGs) use remains uncertain in patients without prior chronic kidney disease (CKD). Therefore, we explored the outcomes of AGs use on AKI episodes associated with renal recovery and progress in patients without prior CKD in Taiwan. This was a retrospective cohort study by using the Taipei Medical University Research Database from January 2008 to December 2019. 43,259 individuals without CKD who had received parenteral AGs were enrolled. The exposed and unexposed groups underwent propensity score matching for age, gender, patients in intensive care unit/emergency admission, and covariates, except serum hemoglobin and albumin levels. We identified an exposed group of 40,547 patients who used AGs (median age, 54.4 years; 44.3% male) and an unexposed group of 40,547 patients without AG use (median age, 55.7 years; 45.5% male). There was the risk for AKI stage 1 (adjusted hazard ratio [HR] 1.34; 95% confidence interval [CI] 1.00–1.79; p?=?0.05) in patients that used AGs in comparison with the control subjects. Moreover, patients using AGs were significantly associated neither with the progression to acute kidney disease (AKD) stages nor with the progression to end-stage renal disease (ESRD) on dialysis. Further analyzed, there was an increased risk of AKI episodes for serum albumin levels less than 3.0 g/dL and hemoglobin levels less than 11.6 g/dL. Among patients without prior CKD, AGs-used individuals were associated with AKI risks, especially those at relatively low albumin (<?3.0 g/dL) or low hemoglobin (<?11.6 g/dL). That could raise awareness of AGs prescription in those patients in clinical practice. |
| 關聯: | Scientific Reports?volume?12, Article?number:?17212?(2022) |
| 描述: | 【111-2 升等】臺北醫學大學教師升等專門著作
職別：專任教師
送審等級：副教授
著作送審 |
| 資料類型: | article |
| 顯示於類別: | [教師升等送審著作] 111
|
文件中的檔案:
| 檔案 |
描述 |
大小 | 格式 | 瀏覽次數 |
|---|
| index.html | | 0Kb | HTML | 1 | 檢視/開啟 |
|
在TMUIR中所有的資料項目都受到原著作權保護.
|
