Strategic infarct location for post-stroke seizure

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題名:	Strategic infarct location for post-stroke seizure
作者:	彭徐鈞 Chien-Chen Chou, Yen-Cheng Shih, Hsu-Huai Chiu, Hsiang-Yu Yu, I-Hui Lee, Yung-Yang Lin, Cheng-Chia Lee, Syu-Jyun Peng
貢獻者:	人工智慧醫療碩士在職專班
關鍵詞:	Keywords: Cerebral infarction;Epileptogenesis;Ischemic stroke;Post-stroke epilepsy;Risk factors
日期:	2022-01
上傳時間:	2025-03-28 16:56:29 (UTC+8)
摘要:	Abstract Post-stroke seizure (PSS) can have a strong negative impact on functional recovery after stroke. Researchers have identified numerous risk factors of PSS; however, the relationship between infarction location and PSS remains unclear. We recruited patients who presented with an acute cerebral infarction between 2012 and 2017 and suffered from seizures within 1 year after stroke (PSS group). PSS group was subgrouped into early-PSS and late-PSS groups based on the interval between seizure and stroke. We also recruited an equal number of acute cerebral infarction patients without post-stroke seizures during the follow-up period (Non-PSS group). All brain MRIs from the two groups were processed, whereupon normalized infarct maps from the PSS and Non-PSS groups were compared via voxel- and volumetric-based analyses. A total of 132 subjects were enrolled in the study, including PSS (n = 66, consisting of 31 early-PSS and 35 late-PSS) and Non-PSS (n = 66) patients. No significant differences were observed between the two groups in terms of stroke lateralization or severity. Image analysis revealed that the volume of infarction was larger in the PSS group than in the Non-PSS group; however, the difference did not reach the level of significance. Unlike the Non-PSS group, the PSS group presented hot spots over the left central region, left superior parietal lobule, and right frontal operculum. We observed differences between the distribution of hot spots among patients with early-PSS and those with late-PSS. We found that some brain regions were significantly associated with the development of PSS after ischemic stroke, and these regions differed between cases of early and late PSS. It appears that the location of infarction could help clinicians assess the risk of PSS in specific post-stroke stages.
關聯:	Neuroimage Clin. 2022 ; 35 : 103069
描述:	【111-2 升等】臺北醫學大學教師升等專門著作職別：專任教師送審等級：副教授著作送審
資料類型:	article
顯示於類別:	[教師升等送審著作] 111

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