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| 題名: | Immune-mediated axonal dysfunction in seropositive and seronegative primary Sj?gren's syndrome. |
| 作者: | 宋家瑩
Jowy Tani, Hsien-Tzung Liao, Hui-Ching Hsu, Lung-Fang Chen, Tsui-San Chang, Cindy Shin-Yi Lin, Jia-Ying Sung |
| 貢獻者: | 醫學系神經學科 |
| 日期: | 2020-05 |
| 上傳時間: | 2025-03-28 16:42:43 (UTC+8) |
| 摘要: | Abstract
Objective: The present study investigates the peripheral neuropathy in Primary Sj?gren's syndrome (pSS) using the nerve excitability test to further elucidate how peripheral nerves are affected by the autoantibodies.
Methods: Each patient received clinical evaluation, examination for anti-SSA/Ro and anti-SSB/La antibodies titer, paired motor and sensory nerve excitability test, thermal quantitative sensory test (QST), and nerve conduction study (NCS).
Results: A total of 40 pSS patients wasenrolled. Motor axonal study of the pSS with positive anti-SSA/Ro or anti-SSB/La antibodies (n = 28) was found to have increased stimulus for 50% compound muscle action potential (CMAP) (P < 0.05), increased rheobase (P < 0.01), increased minimum I/V slope (P < 0.01) and hyperpolarizing I/V slope (P < 0.05), increased relative refractory period (RRP, P < 0.001), decreased accommodation of threshold electrotonus toward depolarizing current (P < 0.05), and increased accommodation toward hyperpolarizing current (P < 0.05). Seronegative pSS (n = 10) showed much less prominent motor axonal changes, showing only increased minimum I/V slope (P < 0.05). Sensory axonal study in seropositive pSS patients is found to have increased stimulus for 50% sensory nerve action potential (SNAP) (P < 0.01), decreased latency (P < 0.01), increased RRP (P < 0.01), and increased subexcitability (P < 0.05). Seronegative pSS patients have shown no significant sensory axonal changes. Thermal QST showed more prominent abnormalities in seronegative pSS compared to seropositive pSS.
Interpretation: Anti-SSA/Ro and anti-SSB/La autoantibodies might cause dysfunction in nodal and internodal region of the axon and small nerve fibers; meanwhile, autoreactive antibodies in seronegative pSS mainly affect small nerve fibers. Thus, the underlying pathophysiology for the two types of pSS is different. |
| 關聯: | Ann Clin Transl Neurol. 2020 May ; 7(5) : 819-828 |
| 描述: | 【111-2 升等】臺北醫學大學教師升等專門著作
職別：專任教師
送審等級：教授
著作送審 |
| 資料類型: | article |
| 顯示於類別: | [教師升等送審著作] 111
[神經學科] 期刊論文
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