| 题名: | Use of Preoperative PET-CT and Survival of p16-Negative Oropharyngeal Cancer |
| 作者: | 陳聰明
Tsung-Ming Chen, Wan-Ming Chen, Mingchih Chen, Ben-Chang Shia, Szu-Yuan Wu |
| 贡献者: | 醫學系耳鼻喉學科 |
| 关键词: | Keywords:?Preoperative,?18FDG PET/CT, OPSCC, survival, clinical stages |
| 日期: | 2022-10 |
| 上传时间: | 2025-03-28 13:49:06 (UTC+8) |
| 摘要: | Abstract
No comparative study with a long-term follow-up period has evaluated the survival outcomes of preoperative 18-fluorodeoxyglucose positron emission tomography/computed tomography (18FDG PET/CT) in patients with p16-negative OPSCC. We included patients with stage I-IVB p16-negative OPSCC undergoing surgery and categorized them into two groups based on whether they underwent preoperative 18FDG PET/CT and compared their outcomes: the case group comprised patients who did not undergo preoperative 18FDG PET/CT, whereas the control group comprised patients who underwent preoperative 18FDG PET/CT. The findings of the multivariable Cox regression analysis revealed no association between preoperative 18FDG PET/CT and overall survival (OS) in the case and control groups in the patients with stage I-III p16-negative OPSCC undergoing surgery (after multivariable adjustment, the hazard ratio [HR] was 1.12; 95% confidence interval [CI] = 0.86-1.48: P = 0.4028). However, we noted an association between preoperative 18FDG PET/CT and OS in the case and control groups in the patients with stage IVA and IVB p16-negative OPSCC undergoing surgery (after multivariable adjustment, the HR of all-cause mortality for nonpreoperative PET/CT was 1.82 compared with preoperative PET/CT; 95% CI = 1.47-2.26; P < 0.0001). Preoperative 18FDG PET/CT use was associated with a lower risk of mortality in the patients with stage IVA and IVB p16-negative OPSCC without metastasis. |
| 關聯: | Am J Cancer Res. 2022 Oct 15;12(10):4775-4788 |
| 描述: | 【112 新聘】臺北醫學大學教師升等專門著作
職別：專任
送審等級：助理教授
著作送審 |
| 数据类型: | article |
| 显示于类别: | [教師升等送審著作] 112
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