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| 題名: | Risk and outcomes of diabetes in patients with epilepsy |
| 作者: | 李俊成
Chun-Cheng Li, Chuen-Chau Chang, Yih-Giun Cherng, Chao-Shun Lin, Chun-Chieh Yeh, Yi-Cheng Chang, Chaur-Jong Hu, Chun-Chuan Shih, Ta-Liang Chen & Chien-Chang Liao |
| 貢獻者: | 醫學系麻醉學科 |
| 日期: | 2021-09 |
| 上傳時間: | 2025-03-28 10:59:29 (UTC+8) |
| 摘要: | Abstract
The risk and outcomes of diabetes in patients with epilepsy remains unclear. We evaluated these risks using an epilepsy cohort analysis and a diabetes admission analysis. In the epilepsy cohort analysis, we identified 2854 patients with newly diagnosed epilepsy in 2000–2008 from the research data of National Health Insurance in Taiwan. Using Propensity-score matching by sociodemographic factors and medical conditions, we selected 22,832 people without epilepsy as a non-exposed cohort for comparison. Follow-up events of diabetes from January 1, 2000 until December 31, 2013 were ascertained from medical claims. The adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of diabetes associated with epilepsy were calculated using multiple Cox proportional hazard models. In the diabetes admission analysis, we identified 92,438 hospitalized diabetes patients, 930 of whom had a history of epilepsy. Adjusted odds ratios (ORs) and 95% CIs of adverse events after diabetes associated with previous epilepsy were calculated using multiple logistic regressions. The adjusted HR of diabetes in the cohort with epilepsy was 1.31 (95% CI 1.14–1.50) compared to the non-epilepsy cohort. Previous epilepsy was associated with post-diabetes adverse events, such as pneumonia (OR 1.68, 95% CI 1.37–2.07), urinary tract infection (OR 1.83, 95% CI 1.55–2.16), and septicemia (OR 1.34, 95% CI 1.09–1.65). In conclusion, epilepsy was associated with higher risk of diabetes and adverse post-diabetes outcomes. Diabetes prevention and attention to post-diabetes adverse events are needed for this susceptible population. |
| 關聯: | Scientific Reports?volume?11, Article?number:?18888?(2021) |
| 描述: | 【112 新聘】臺北醫學大學教師升等專門著作
職別：兼任
送審等級：講師
著作送審 |
| 資料類型: | article |
| 顯示於類別: | [教師升等送審著作] 112
[麻醉學科] 期刊論文
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