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| 題名: | Abnormal functional relationship of sensorimotor network with neurotransmitter-related nuclei via subcorticalcortical loops in manic and depressive phases of bipolar disorder |
| 作者: | Magioncalda, Paola
Matteo Martino, Paola Magioncalda, Benedetta Conio, Laura Capobianco, Daniel Russo, Giulia Adavastro, Shankar Tumati, Zhonglin Tan, Hsin-Chien Lee, Timothy J Lane, Mario Amore, Matilde Inglese, Georg Northoff |
| 貢獻者: | 國際醫學研究博士學位學程 |
| 關鍵詞: | Keywords：bipolar disorder, psychomotricity, functional connectivity, sensorimotor network, thalamus, neurotransmitters-related areas |
| 日期: | 2019-05 |
| 上傳時間: | 2025-03-27 15:27:36 (UTC+8) |
| 摘要: | Abstract
Objective
Manic and depressive phases of bipolar disorder (BD) show opposite psychomotor symptoms. Neuronally, these may depend on altered relationships between sensorimotor network (SMN) and subcortical structures. The study aimed to investigate the functional relationships of SMN with substantia nigra (SN) and raphe nuclei (RN) via subcortical-cortical loops, and their alteration in bipolar mania and depression, as characterized by psychomotor excitation and inhibition.
Method
In this resting-state functional magnetic resonance imaging (fMRI) study on healthy (n = 67) and BD patients (n = 100), (1) functional connectivity (FC) between thalamus and SMN was calculated and correlated with FC from SN or RN to basal ganglia (BG)/thalamus in healthy; (2) using an a-priori-driven approach, thalamus-SMN FC, SN-BG/thalamus FC, and RN-BG/thalamus FC were compared between healthy and BD, focusing on manic (n = 34) and inhibited depressed (n = 21) patients.
Results
(1) In healthy, the thalamus-SMN FC showed a quadratic correlation with SN-BG/thalamus FC and a linear negative correlation with RN-BG/thalamus FC. Accordingly, the SN-related FC appears to enable the thalamus-SMN coupling, while the RN-related FC affects it favoring anti-correlation. (2) In BD, mania showed an increase in thalamus-SMN FC toward positive values (ie, thalamus-SMN abnormal coupling) paralleled by reduction of RN-BG/thalamus FC. By contrast, inhibited depression showed a decrease in thalamus-SMN FC toward around-zero values (ie, thalamus-SMN disconnection) paralleled by reduction of SN-BG/thalamus FC (and RN-BG/thalamus FC). The results were replicated in independent HC and BD datasets.
Conclusions
These findings suggest an abnormal relationship of SMN with neurotransmitters-related areas via subcortical-cortical loops in mania and inhibited depression, finally resulting in psychomotor alterations. |
| 關聯: | Schizophrenia Bulletin, Volume 46, Issue 1, January 2020, Pages 163–174 |
| 描述: | 【112 新聘】臺北醫學大學教師升等專門著作
職別：專任
送審等級：助理教授
著作送審 |
| 資料類型: | article |
| 顯示於類別: | [教師升等送審著作] 112
[國際醫學研究碩博士學位學程] 期刊論文
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