A 45-year experience of uveal melanoma in Taiwan: Verification of American Joint Committee on Cancer staging system and prognostic factors

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Title:	A 45-year experience of uveal melanoma in Taiwan: Verification of American Joint Committee on Cancer staging system and prognostic factors
Authors:	馬尚德 Shang-Te Ma, Yi-Ting Hsieh, Yi-Hsuan Wei, Shu-Lang Liao
Contributors:	醫學系眼科學科
Keywords:	Keywords: Ciliary body;Melanoma;Neoplasm metastases;Uvea neoplasms
Date:	2021-06
Issue Date:	2025-03-27 15:27:35 (UTC+8)
Abstract:	Abstract: Background/Purpose To verify the staging system of the American Joint Committee on Cancer (AJCC) 8th edition for uveal melanoma, and to propose the prognostic factors of uveal melanoma by a 45-year cohort study. Methods We collected patients who underwent operation with pathological proof from 1973 to 2017. The demographic data including gender, age, laterality, metastatic pattern, and histopathology type were recorded. The predictability for survival and monotonicity of gradients of the AJCC 8th edition were evaluated. The prognostic factors for survival were analyzed by univariate and multivariate analysis. Results A total of 72 patients were collected. The median age was 55 year-old (range 24–100). No specific gender predilection was revealed in our study. About 75.9% of metastases events happened in the first five-year of follow-up, and hepatic involvement was the most common. By the AJCC 8th edition, the distribution for stage I: II: III was 8 (11.1%), 37 (51.4%), and 27 (37.5%). The prognostic staging groups manifested fair predictability and monotonicity of gradients for survival outcome. The tumors with epithelioid cell type and ciliary body involvements had higher tumor-related mortality. Conclusion The AJCC 8th edition prognostic staging groups for outcome prediction was validated. Periodic screening for metastases should be more frequent in the first five-year follow-up. The tumors with epithelioid cell pattern and ciliary body involvements were at risk of higher tumor-related mortality in Taiwanese patients.
Relation:	Journal of the Formosan Medical Association, Volume 120, Issue 6, 2021, Pages 1361-1368
Description:	【112 新聘】臺北醫學大學教師升等專門著作職別：兼任送審等級：講師著作送審
Data Type:	article
Appears in Collections:	[Scholarly output for promotion] 112 [Department of Ophthalmology] Periodical Articles

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