The combined effects of nucleotide-binding domain-like receptor protein 3 polymorphisms and levels of blood lead on developmental delays in preschool children

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題名:	The combined effects of nucleotide-binding domain-like receptor protein 3 polymorphisms and levels of blood lead on developmental delays in preschool children
作者:	林英欽 Yu-Mei Hsueh, Wei-Jen Chen, Chi-Jung Chung, Ru-Lan Hsieh, Hsi-Hsien Chen, Ya-Li Huang, Horng-Sheng Shiue, Ming-I Lin, Shu-Chi Mu, Ying-Chin Lin
貢獻者:	醫學系家庭醫學科
關鍵詞:	Keywords: Nucleotide binding domain-like receptor protein 3;PolymorphismLead;Arsenic;Developmental delay;Preschool children
日期:	2022-02
上傳時間:	2025-03-27 13:42:32 (UTC+8)
摘要:	Abstract: Nucleotide-binding domain-like receptors protein 3 (NLRP3) inflammasomes are associated with neuroinflammation and multiple NLRP3 genes regulate NLRP3 expression. Our study aimed to investigate the association of NLRP3 polymorphisms with developmental delay in preschool children. We also explored whether NLRP3 polymorphisms modified the effects of total urinary arsenic and blood cadmium and lead to developmental delays. A total of 178 children with developmental delays and 88 healthy children were analyzed for urinary arsenic concentrations and red blood cell lead and cadmium concentrations. We examined the genotypes of fifteen common single-nucleotide polymorphisms in NLRP3. We observed that levels of total urinary arsenic and blood lead were significantly associated with developmental delay. The NLRP3rs10754555 CG versus CC/GG, NLRP3rs12048215 AG versus AA/GG, and NLRP3rs12137901 TC/TT versus CC genotype showed a lower odds of developmental delay, with the odds ratio (OR) and 95% confidence interval (CI) =?0.38 (0.19–0.75), 0.52 (0.27–0.99), and 0.33 (0.12–0.90), respectively. Children with the NLRP3rs10754555 CC/GG genotype and high blood lead levels had a significant multiplicative interaction with developmental delay [OR (95% CI) =?9.74 (3.59–26.45)]. This study found evidence that suggested the joint effects of NLRP3rs10754555 CC/GG genotype and high blood lead levels on developmental delays.
關聯:	Journal of Hazardous Materials, Volume 424, Part A, 2022, 127317
描述:	【112-2 升等】臺北醫學大學教師升等專門著作職別：專任送審等級：教授著作送審
資料類型:	article
顯示於類別:	[教師升等送審著作] 112 [家庭醫學科] 期刊論文

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