Lonicerae Japonicae Flos Attenuates Neutrophilic Inflammation by Inhibiting Oxidative Stress

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题名:	Lonicerae Japonicae Flos Attenuates Neutrophilic Inflammation by Inhibiting Oxidative Stress
作者:	賴奎宏 Kuei-Hung Lai, Yu-Li Chen, Mei-Fang Lin, Mohamed El-Shazly, Yu-Chia Chang, Po-Jen Chen, Chun-Han Su, Yen-Chun Chiu, Amina M. Illias, Chih-Chuan Chen, Lo-Yun Chen and Tsong-Long Hwang
贡献者:	中草藥臨床藥物研發博士學位學程
关键词:	Keywords: Lonicerae japonicae flos;human neutrophils;superoxide anion;calcium mobilization;SARS-CoV-2-Spike/ACE2;bioassay-coupled chromatographic profile
日期:	2022-09
上传时间:	2025-03-27 10:36:19 (UTC+8)
摘要:	Abstract Lonicerae japonicae flos (LJ) is an Asian traditional herb that is used as a dietary supplement, tea, and beverage to clear heat and quench thirst. However, no studies investigated its effect on activated human neutrophils, which played a crucial role in the bad prognosis of coronavirus disease of 2019 (COVID-19) patients by aggravating lung inflammation and respiratory failure. Herein, we evaluated the anti-inflammatory effect of LJ ethanol extract (LJEE) on human neutrophils activated by N-formyl-methionyl-leucyl-phenylalanine (fMLF). Our experimental results indicated that LJEE suppressed fMLF-activated superoxide anion (O2??) generation, the expression of CD11b, and cell adhesion and migration, as well as the formation of neutrophil extracellular traps in human neutrophils. Further in-depth mechanical investigation revealed that pretreatment with LJEE accelerated the Ca2+ clearance, but did not affect the phosphorylation of mitogen-activated protein kinases (MAPKs) and protein kinase B (Akt) in activated human neutrophils. In addition, LJEE displayed a dose-dependent reactive oxygen species (ROS) scavenger activity, which assisted its anti-inflammatory activity. From the bioassay-coupled chromatographic profile, chlorogenic acids were found to dominate the anti-inflammatory effects of LJEE. Moreover, LJ water extract (LJWE) demonstrated an interrupting effect on the severe acute respiratory syndrome coronavirus-2 spike protein (SARS-CoV-2-Spike)/angiotensin-converting enzyme 2 (ACE2) binding. In conclusion, the obtained results not only supported the traditional use of LJ for heat-clearance, but also suggested its potential application in daily health care during the COVID-19 pandemic.
關聯:	Antioxidants 2022, 11(9), 1781
描述:	【112-1 升等】臺北醫學大學教師升等專門著作職別：專任送審等級：副教授著作送審
数据类型:	article
显示于类别:	[教師升等送審著作] 112 [中草藥臨床藥物研發博士學位學程] 期刊論文

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