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| 題名: | Interleukin?11/gp130 upregulates MMP?13 expression and cell migration in OSCC by activating PI3K/Akt and AP?1 signaling |
| 作者: | 吳家佑
Chia-Yu Wu, Ju-Fang Liu, Hsiao-Chi Tsai, Huey-En Tzeng, Tsung-Han Hsieh, Ming Wang, Yu-Feng Lin, Chien-Chi Lu, Ming-Yu Lien, Chih-Hsin Tang |
| 貢獻者: | 牙體技術學系 |
| 日期: | 2022-12 |
| 上傳時間: | 2025-03-27 09:55:54 (UTC+8) |
| 摘要: | Abstract
Oral squamous cell carcinoma (OSCC) is an extremely common head and neck cancer with a poor 5-year survival rate, especially in cases of metastatic disease. Interleukin (IL)-11 reportedly promotes cell growth and the epithelial–mesenchymal transition process in metastasis. However, the molecular mechanisms of IL-11 in OSCC metastasis are unclear. This study found that IL-11 upregulates matrix metalloproteinase 13 (MMP-13) expression in OSCC via the IL-11 receptor alpha subunit/glycoprotein 130 receptors that activate phosphatidyl-inositol 3-kinase, Ak strain transforming, and activator protein 1 signaling, which subsequently enhance MMP-13-induced tumor metastasis. TIMER2.0 analysis revealed a positive correlation between MMP-13 and IL-11 levels (r?=?0.454). Moreover, a strong positive association was observed between higher levels of IL-11 expression in OSCC tissue (p?<?0.01), lymph node metastasis (p?=?0.0154), and clinical disease stage (p?=?0.0337). IL-11 knockdown suppressed the migration of OSCC cells (p?<?0.05). The evidence indicates that IL-11 can serve as a new molecular therapeutic target in OSCC metastasis. |
| 關聯: | Journal of Cellular Physiology, Volume237, Issue12 , December 2022 , Pages 4551-4562 , First published: 19 October 2022 |
| 描述: | 【112-1 升等】臺北醫學大學教師升等專門著作
職別：專任
送審等級：副教授
著作送審 |
| 資料類型: | article |
| 顯示於類別: | [教師升等送審著作] 112
[牙體技術學系] 期刊論文
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