Taipei Medical University Institutional Repository:Item 987654321/6505
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 45073/58249 (77%)
造访人次 : 2385143      在线人数 : 175
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://libir.tmu.edu.tw/handle/987654321/6505


    题名: 氟白普洛芬於醇性溶媒之光解研究
    Photolytic Studies of Flurbiprofen in Alcoholic Solvents
    作者: 游逸群
    Yu Yi Chun
    贡献者: 藥學研究所
    关键词: 氟白普洛芬
    光解反應
    非固醇類抗發炎藥
    高效液相層析法
    Flurbiprofen
    Photolysis
    NSAIDs
    HPLC
    日期: 2004
    上传时间: 2009-09-11 16:57:45 (UTC+8)
    摘要: 中文摘要
    氟白普洛芬（FB）為一具有光敏感特性的非類固醇抗發炎藥物（NSAIDs）。為發展一敏感度高、準確的安定性指標之高壓液相層析分析法，並藉此來定量氟白普洛芬並觀察其光解反應。液相層析方法是使用Inertsil ODS-3V管柱，移動相組成為甲醇：氰甲烷：純水（加入1%醋酸）為2:4:4，UV檢測器波長設定在247nm。進而將氟白普洛芬檢量線作線性回歸、日內及日間精密度（Precision）試驗並予以確效。檢量線的R2值為0.9984，而日內、日間試驗的C.V.(%)值皆低於2.5% 和3.2%，模擬回收率亦在99.35%~101.61%之間。以上結果顯示，已發展出的HPLC分析方法具有良好的選擇性和專一性。
    當將氟白普洛芬之甲醇溶液以Philips 400-W紫外燈照射，可觀察到氟白普洛芬有醇基（FB-1）、酮基（FB-2）及酯類（FB-3）三種光解衍生產物的產生。而當於乙醇溶液，酸性條件下，亦可觀察到氟白普洛芬乙基酯（FB-4）的生成。這些光解產物除以製備型高壓液相層析系統逐一單離，之後並藉由EI-MS、UV、IR、1H-,13C-NMR之檢測來解析其化學結構。
    以不同濃度、不同溶媒的兩項變異，來觀察氟白普洛芬之光解動力學情形。結果發現，氟白普洛芬於高濃度對進行光分解會呈現零階次動力學模式，低濃度則較偏向一階次動力學模式；藉由使用不同醇類溶媒作仔細的觀察，則可看到其動力學模式，隨著溶媒極性的降低，而較偏向一階次動力學模式。
    Abstract
    Flurbiprofen (FB) is one of photosensitizing non-steroidal anti-inflammatory drugs (NSAIDs). A sensitive, and accurate stability-indicating high performance liquid chromatography for determining the photodegradation of FB was developed and validated with linear regression of calibration curve, intra-day test, inter-day test. The quantitation for FB was monitored with an Inertsil ODS-3V column. The component of mobile phase was methanol- acetonitrile -deionized water (with 1% acetic acid added) = 2:4:4 and setting of UV detector was 247 nm. The R square of calibration curve regression was 0.9984 and the C.V. (%) of intra-day and inter-day tests was lower than 2.5% and 3.2%, respectively. The mimic percent recovery were between 99.35%~101.61%. The above results showed that our established HPLC assay method exhibit good selectivity and specificity.
    When FB was irradiated with a Philips 400-W UV lamp in methanol, 3 photoproducts of FB; ketone (FB-1), aldehyde (FB-2) and methyl ester (FB-3) could be observed, respectively. FB-ethyl ester (FB-4) also could be observed, when FB was dissolved in ethanol in acidic condition. Using preparative HPLC system, the resulting photoproducts were isolated and their chemical structures were analyzed by EI-MS、UV、IR、1H-,13C-NMR spectroscopies.
    Under the conditions of different concentrations and various alcoholic solvents, the photo-kinetic behaviors of FB were observed. The kinetics of FB under the photo-irradiation conditions followed the first order at lower concentrations. The kinetic results of FB followed the first order in n-propanol and zeroth order in methanol solutions.
    数据类型: thesis
    显示于类别:[藥學系] 博碩士論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    摘要.doc28KbMicrosoft Word95检视/开启
    摘要.pdf68KbAdobe PDF123检视/开启
    摘要.ppt105KbMicrosoft Powerpoint89检视/开启
    摘要.ps388KbPostscript33检视/开启


    在TMUIR中所有的数据项都受到原著作权保护.

    TAIR相关文章

    著作權聲明 Copyright Notice

    • 本平台之數位內容為臺北醫學大學所收錄之機構典藏，包含體系內各式學術著作及學術產出。秉持開放取用的精神，提供使用者進行資料檢索、下載與取用，惟仍請適度、合理地於合法範圍內使用本平台之內容，以尊重著作權人之權益。商業上之利用，請先取得著作權人之授權。

      The digital content on this platform is part of the Taipei Medical University Institutional Repository, featuring various academic works and outputs from the institution. It offers free access to academic research and public education for non-commercial use. Please use the content appropriately and within legal boundaries to respect copyright owners' rights. For commercial use, please obtain prior authorization from the copyright owner.

    • 瀏覽或使用本平台，視同使用者已完全接受並瞭解聲明中所有規範、中華民國相關法規、一切國際網路規定及使用慣例，並不得為任何不法目的使用TMUIR。

      By utilising the platform, users are deemed to have fully accepted and understood all the regulations set out in the statement, relevant laws of the Republic of China, all international internet regulations, and usage conventions. Furthermore, users must not use TMUIR for any illegal purposes.

    • 本平台盡力防止侵害著作權人之權益。若發現本平台之數位內容有侵害著作權人權益情事者，煩請權利人通知本平台維護人員([email protected])，將立即採取移除該數位著作等補救措施。

      TMUIR is made to protect the interests of copyright owners. If you believe that any material on the website infringes copyright, please contact our staff([email protected]). We will remove the work from the repository.

    Back to Top
    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈