The Gram-positive bacterium Romboutsia ilealis harbors a polysaccharide synthase that can produce (1,3;1,4)-β-D-glucans

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題名:	The Gram-positive bacterium Romboutsia ilealis harbors a polysaccharide synthase that can produce (1,3;1,4)-β-D-glucans
作者:	謝尚逸 Chang, Shu-Chieh;Kao, Mu-Rong;Saldivar, Rebecka Karmakar;Sara, M D?az-Moreno;Xing, Xiaohui;Furlanetto, Valentina;Yayo, Johannes;Divne, Christina;Vilaplana, Francisco;Abbott, D Wade;Hsieh, Yves S Y
貢獻者:	藥學系藥物科學學科
日期:	2023-07
上傳時間:	2024-12-04 14:05:59 (UTC+8)
摘要:	(1;3;1;4)-β-D-Glucans are widely distributed in the cell walls of grasses (family Poaceae) and closely related families; as well as some other vascular plants. Additionally; they have been found in other organisms; including fungi; lichens; brown algae; charophycean green algae; and the bacterium Sinorhizobium meliloti. Only three members of the Cellulose Synthase-Like (CSL) genes in the families CSLF; CSLH; and CSLJ are implicated in (1;3;1;4)-β-D-glucan biosynthesis in grasses. Little is known about the enzymes responsible for synthesizing (1;3;1;4)-β-D-glucans outside the grasses. In the present study; we report the presence of (1;3;1;4)-β-D-glucans in the exopolysaccharides of the Gram-positive bacterium Romboutsia ilealis CRIBT. We also report that RiGT2 is the candidate gene of R. ilealis that encodes (1;3;1;4)-β-D-glucan synthase. RiGT2 has conserved glycosyltransferase family 2 (GT2) motifs; including D; D; D; QXXRW; and a C-terminal PilZ domain that resembles the C-terminal domain of bacteria cellulose synthase; BcsA. Using a direct gain-of-function approach; we insert RiGT2 into Saccharomyces cerevisiae; and (1;3;1;4)-β-D-glucans are produced with structures similar to those of the (1;3;1;4)-β-D-glucans of the lichen Cetraria islandica. Phylogenetic analysis reveals that putative (1;3;1;4)-β-D-glucan synthase candidate genes in several other bacterial species support the finding of (1;3;1;4)-β-D-glucans in these species.
關聯:	Nature communications; 14(1); 4526
描述:	【112-2 升等】臺北醫學大學教師升等專門著作職別：專任送審等級：教授著作送審
附註:	代表著作名稱：《The Gram-positive bacterium Romboutsia ilealis harbors a polysaccharide synthase that can produce (1,3;1,4)-β-D-glucans》 ? 2023. The Author(s).
資料類型:	article
顯示於類別:	[教師升等送審著作] 112 [藥學系] 期刊論文

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