Sex-specific risk profiles for suicide mortality in bipolar disorder: incidence, healthcare utilization and comorbidity

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題名:	Sex-specific risk profiles for suicide mortality in bipolar disorder: incidence, healthcare utilization and comorbidity
作者:	陳抱寰 Chen, Pao-Huan;Tsai, Shang-Ying;Pan, Chun-Hung;Chen, Yi-Lung;Chang, Hu-Ming;Su, Sheng-Siang;Chen, Chiao-Chicy;Kuo, Chian-Jue
貢獻者:	醫學院醫學系精神學科
關鍵詞:	Bipolar disorder;comorbidity;incidence;mortality rate ratio;sex-stratified;suicide
日期:	2023-05
上傳時間:	2024-12-04 14:05:53 (UTC+8)
摘要:	Background: Evidence on sex-specific incidence and comorbidity risk factors of suicide among patients with bipolar disorder is scarce. This study investigated the sex-specific risk profiles for suicide among the bipolar disorder population in terms of incidence; healthcare utilization and comorbidity. Methods: Using data from the Taiwan National Health Insurance Research Database between 1 January 2000 and 31 December 2016; this nationwide cohort study included patients with bipolar disorder (N = 46 490) and individuals representative of the general population (N = 185 960) matched by age and sex at a 1:4 ratio. Mortality rate ratios (MRRs) of suicide were calculated between suicide rates of bipolar disorder cohort and general population. In addition; a nested case-control study (1428 cases died by suicide and 5710 living controls) was conducted in the bipolar disorder cohort to examine the sex-specific risk of healthcare utilization and comorbidities. Results: Suicide risk was considerably higher in the cohort (MRR = 21.9) than in the general population; especially among women (MRR = 35.6). Sex-stratified analyses revealed distinct healthcare utilization patterns and physical comorbidity risk profiles between the sexes. Although female patients who died by suicide had higher risks of nonhypertensive cardiovascular disease; pneumonia; chronic kidney disease; peptic ulcer; irritable bowel syndrome; and sepsis compared to their living counterparts; male patients who died by suicide had higher risks of chronic kidney disease and sepsis compared to the living controls. Conclusions: Patients with bipolar disorder who died by suicide had sex-specific risk profiles in incidence and physical comorbidities. Identifying these modifiable risk factors may guide interventions for suicide risk reduction.
關聯:	Psychological medicine; 53(4); 1500–1509
描述:	【112-2 升等】臺北醫學大學教師升等專門著作職別：專任送審等級：副教授著作送審
附註:	代表著作名稱：《Sex-specific risk profiles for suicide mortality in bipolar disorder: incidence, healthcare utilization and comorbidity》
資料類型:	article
顯示於類別:	[教師升等送審著作] 112

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