Sex differences in the associations between psychological symptoms and tumor necrosis factor-alpha levels among obese and nonobese children aged 6-13 in Taiwan

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題名:	Sex differences in the associations between psychological symptoms and tumor necrosis factor-alpha levels among obese and nonobese children aged 6-13 in Taiwan
作者:	鐘國軒 Chen, Yi-Hua;Chiou, Hung-Yi;Wang, Hsin-Yi;Chung, Kuo-Hsuan
貢獻者:	醫學系精神學科
關鍵詞:	Adolescents;Anxiety;Children;Obesity;Sex differences;Tumor necrosis factor alpha (TNF-α).
日期:	2023-01
上傳時間:	2024-12-04 14:05:48 (UTC+8)
摘要:	Background: Evidence of associations between psychological symptoms and tumor necrosis factor (TNF)-α level is scant; as is evidence on sex differences in associations for children and adolescents with obesity. This study examined sex differences in associations between psychological symptoms (self-concept; anxiety; depression; anger; and disruptive behavior) and TNF-α level in Taiwanese children and adolescents with healthy weight; overweight; or obesity. Methods: In 2010; 564 first; fourth; and seventh graders-comprising 250 children with overweight or obesity (44.3 %); 330 adolescents (58.5 %); and 303 males (53.7 %)-underwent a health examination and blood sampling and completed a questionnaire. Results: A significantly higher TNF-α level was found in children and adolescents with healthy weight than in those with overweight or obesity (median: 14.5 vs. 4.1 (pg/mL); p < 0.001). In multiple linear regression models; anxiety was significantly positively associated with TNF-α level in female participants with healthy weight (β = 0.11 per 10 increments in anxiety; 95 % confidence interval = 0.01-0.22). Limitations: Given the cross-sectional nature of the study; no inferences of causal relationships among TNF-α level; obesity; and psychological symptoms could be made. Conclusions: The findings enrich the literature on the TNF-α-psychological symptom association. Sex differences were found in children and adolescents without obesity rather than in those without obesity; and a higher TNF-α level was associated with increased anxiety in girls without obesity. The role of sex differences in the complex associations among psychological symptoms; TNF-α level; and overweight or obesity requires further investigation.
關聯:	Journal of affective disorders; 320; 241–246
描述:	【112-2 升等】臺北醫學大學教師升等專門著作職別：專任送審等級：教授著作送審
附註:	代表著作名稱：《Sex differences in the associations between psychological symptoms and tumor necrosis factor-alpha levels among obese and nonobese children aged 6-13 in Taiwan》 Copyright ? 2022 Elsevier B.V. All rights reserved.
資料類型:	article
顯示於類別:	[教師升等送審著作] 112 [精神學科] 期刊論文

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