Ribonucleotide reductase M2B in the myofibers modulates stem cell fate in skeletal muscle

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題名:	Ribonucleotide reductase M2B in the myofibers modulates stem cell fate in skeletal muscle
作者:	陳怡帆 Chen, Wan-Jing;Lin, I-Hsuan;Lee, Chien-Wei;Yoshioka, Kiyoshi;Ono, Yusuke;Yan, Yu-Ting;Yen, Yun;Chen, Yi-Fan
貢獻者:	轉譯醫學博士學位學程
日期:	2022-07
上傳時間:	2024-12-04 14:05:41 (UTC+8)
摘要:	The balance among quiescence; differentiation; and self-renewal of skeletal muscle stem cells (MuSCs) is tightly regulated by their intrinsic and extrinsic properties from the niche. How the niche controls MuSC fate remains unclear. Ribonucleotide reductase M2B (Rrm2b) modulates MuSC quiescence/differentiation in muscle in response to injury. Rrm2b knockout in myofibers; but not in MuSCs; led to weakness of muscles; such as a loss of muscle mass and strength. After muscle injury; damaged myofibers were more efficiently repaired in the Rrm2b myofiber-specific knockout mice than the control mice; but these myofibers were thinner and showed weak functioning. Rrm2b-deleted myofibers released several myokines; which trigger MuSCs to differentiate but not re-enter the quiescent stage to replenish the stem cell pool. Overall; Rrm2b in the myofibers plays a critical role in modulating the MuSC fate by modifying the microenvironment; and it may lead to a possible strategy to treat muscle disorders.
關聯:	NPJ Regenerative medicine; 7(1); 37
描述:	【112-2 升等】臺北醫學大學教師升等專門著作職別：專任送審等級：教授著作送審
附註:	代表著作名稱：《Ribonucleotide reductase M2B in the myofibers modulates stem cell fate in skeletal muscle》 ? 2022. The Author(s).
資料類型:	article
顯示於類別:	[教師升等送審著作] 112 [轉譯醫學博士學位學程] 期刊論文

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