Differential Cellular Responses to FDA-Approved Nanomedicines: An Exploration of Albumin-Based Nanocarriers and Liposomes in Protein Corona Formation

English | 正體中文 | 简体中文 | Items with full text/Total items : 45422/58598 (78%)
Visitors : 2522634 Online Users : 185

RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.

Home ‧ Login ‧ Upload ‧ Help ‧ About ‧ Administer

TMUIR > Works submitted for Review > Scholarly output for promotion > 112 > Item 987654321/64816

Please use this identifier to cite or link to this item: http://libir.tmu.edu.tw/handle/987654321/64816

Title:	Differential Cellular Responses to FDA-Approved Nanomedicines: An Exploration of Albumin-Based Nanocarriers and Liposomes in Protein Corona Formation
Authors:	謝堅銘 Putri, Athika Darumas;Hsu, Ming-Jen;Han, Chia-Li;Chao, Fang-Ching;Hsu, Chun-Hua;Lorenz, Christian D;Hsieh, Chien-Ming
Contributors:	藥學系藥物科學學科
Date:	2023-11
Issue Date:	2024-12-04 14:04:38 (UTC+8)
Abstract:	Albumin nanoparticles (NPs) and PEGylated liposomes have garnered tremendous interest as therapeutic drug carriers due to their unique physicochemical properties. These unique properties also have significant effects on the composition and structure of the protein corona formed around these NPs in a biological environment. Herein; protein corona formation on albumin NPs and liposomes was simultaneously evaluated through in vitro and simulation studies. The sizes of both types of NPs increased with more negatively charged interfaces upon being introduced into fetal bovine serum. Gel electrophoresis and label-free quantitative proteomics were performed to identify proteins recruited to the hard corona; and fewer proteins were found in albumin NPs than in liposomes; which is in accordance with isothermal titration calorimetry. The cellular uptake efficiency of the two NPs significantly differed in different serum concentrations; which was further scrutinized by loading an anticancer compound into albumin NPs. The presence of the hard protein corona increased the cellular uptake of albumin NPs in comparison with liposomes. In our simulation study; a specific receptor present in the membrane was greatly attracted to the albumin-apolipoprotein E complex. Overall; this study not only evaluated protein corona formation on albumin NPs; but also made promising advancements toward albumin- and liposome-based therapeutic systems.
Relation:	Nanoscale; 15(44); 17825–17838
Description:	【112-2 升等】臺北醫學大學教師升等專門著作職別：專任送審等級：教授著作送審
Note:	代表著作名稱：《Differential Cellular Responses to FDA-Approved Nanomedicines: An Exploration of Albumin-Based Nanocarriers and Liposomes in Protein Corona Formation》
Data Type:	article
Appears in Collections:	[Scholarly output for promotion] 112 [School of Pharmacy] Periodical Article

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	60	View/Open

著作權聲明 Copyright Notice

本平台之數位內容為臺北醫學大學所收錄之機構典藏，包含體系內各式學術著作及學術產出。秉持開放取用的精神，提供使用者進行資料檢索、下載與取用，惟仍請適度、合理地於合法範圍內使用本平台之內容，以尊重著作權人之權益。商業上之利用，請先取得著作權人之授權。
The digital content on this platform is part of the Taipei Medical University Institutional Repository, featuring various academic works and outputs from the institution. It offers free access to academic research and public education for non-commercial use. Please use the content appropriately and within legal boundaries to respect copyright owners' rights. For commercial use, please obtain prior authorization from the copyright owner.
瀏覽或使用本平台，視同使用者已完全接受並瞭解聲明中所有規範、中華民國相關法規、一切國際網路規定及使用慣例，並不得為任何不法目的使用TMUIR。
By utilising the platform, users are deemed to have fully accepted and understood all the regulations set out in the statement, relevant laws of the Republic of China, all international internet regulations, and usage conventions. Furthermore, users must not use TMUIR for any illegal purposes.
本平台盡力防止侵害著作權人之權益。若發現本平台之數位內容有侵害著作權人權益情事者，煩請權利人通知本平台維護人員([email protected])，將立即採取移除該數位著作等補救措施。
TMUIR is made to protect the interests of copyright owners. If you believe that any material on the website infringes copyright, please contact our staff([email protected]). We will remove the work from the repository.

Loading...