| 摘要: | 在???合研究中，完美地?合了??重要的研究?域：通?生物材料的?用??衰老和治??下???骨??炎（TMJ-OA）。与年?相?的?胞功能障?是一?普遍?注的??，其特?是干?胞衰老和?胞外基?（ECM）?化等??。在此，研究利用?中???中提取的生物材料，??CSDB（硫酸?骨素衍生生物材料），??抗易于加速衰老的SAMP8小鼠的衰老。CSDB具有低分子量和特定的硫酸?骨素?成，表?出?著的抗衰老特性。它通?振?干?胞，?少氧化?激，抑制衰老相?的基因通路，并促?SIRT-1基因表?，?而??衰老?程。在体?研究中，CSDB有助于恢复骨?密度和皮?形?，?而延?健康?命。
与此同?，研究?探索了骨??炎，特?是?下???骨??炎（TMJ-OA）。研究重?是人血小板富集血?（hPRP）和透明?酸（HA）?合?法的有效性。?方法通?体外模型、?物研究和人体???行??。hPRP/HA治?表?出?著的益?，通???炎症，促??骨?胞增殖和再生髁??骨。在人体?床??中，?一步??了?些?极的?果，?示出?骨再生、疼痛??和TMJ-OA患者的?移位改善。
?之，我?的研究??了生物材料在延??命和治?特定疾病如TMJ-OA方面的重要治??力，???室到?床?用提供了??的?解。
In this comprehensive study seamlessly bridges two vital research domains: addressing aging and tackling temporomandibular joint osteoarthritis (TMJ-OA) through the application of biomaterials. Age-related cellular dysfunction is a pervasive concern, characterized by issues like stem cell senescence and alterations in the extracellular matrix (ECM). Here, the study leveraged the potential of biomaterial extracted from Chinese sturgeon fish, known as CSDB (chondroitin sulfate -derived biomaterial) to counteract senescence in SAMP8 mice, which are prone to accelerate senescence. CSDB, boasting a low molecular weight and specific CS composition, demonstrated impressive anti-aging properties. It revitalized stem cells, reduced oxidative stress, suppressed aging-related gene pathways, and promoted SIRT-1 gene expression, thereby decelerating the aging process. In an in vivo context, CSDB contributed to restoring bone mineral density and skin morphology, thus extending healthy longevity.
Simultaneously, the study explored osteoarthritis, with a specific focus on temporomandibular joint osteoarthritis (TMJOA). The research concentrated on the effectiveness of a combination therapy human platelet-rich plasma (hPRP) and hyaluronic acid (HA). This approach tested through clinical trials across in vitro models, animal studies, and human subjects. The hPRP/HA treatment demonstrated remarkable benefits by mitigating inflammation, promoting chondrocyte proliferation, and regenerating condylar cartilage. The clinical trial in human further corroborated these positive outcomes, revealing enhanced cartilage regeneration, pain reduction, and improved disc displacement in TMJ-OA patients.
In summary, our study emphasize the significant therapeutic potential of biomaterial in addressing prolong longevity and specific conditions like TMJ-OA, offering valuable insights from bench to bedside. |
