PHY906與Capecitabine於肝癌的藥理與臨床二期綜合療法研究

Taipei Medical University Institutional Repository > 醫學科技學院 > 癌症生物學與藥物研發博士學位學程 > 博碩士論文 > Item 987654321/63246

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題名:	PHY906與Capecitabine於肝癌的藥理與臨床二期綜合療法研究 Combination Therapy of PHY906 plus Capecitabine in Hepatocellular Carcinoma, a Phase II Clinical Trial Study.
作者:	張歐群 CHANGOU, CHUN AUSTIN
貢獻者:	癌症生物學與藥物研發博士學位學程施景文
關鍵詞:	PHY906
日期:	2023-06-21
上傳時間:	2023-12-07 10:13:15 (UTC+8)
摘要:	PHY906 是一種由四種草藥組成的傳統中藥，已具有 1800 多年的歷史用於緩解各種症狀，如腹部絞痛、發燒、頭痛、嘔吐、口渴和腹瀉。最近的研究顯示，它還具有多種可能的使用，例如增強化學治療劑和靶向劑的抗腫瘤作用，顯示出 PHY906 用於癌症治療的潛力。在之前的美國 I/II 期臨床試驗中，接受 PHY906 配合 Ca[ecitabine 治療的晚期肝細胞癌患者獲得了良好的臨床結果。這些有未來發展性的發現突顯了 PHY906 作為 HCC 有效輔助療法的潛力。為了進一步研究 PHY906 的療效，我們在台灣對 HCC 患者進行了 II 期臨床試驗，旨在驗證這些先前的發現。在通過更大規模的患者隊列中評估 PHY906 的療效，我們可以更全面地了解其在 HCC 治療中的潛在治療價值。這項研究的結果可能有助於為 HCC 以及其他類型的癌症患者開發更有效和個性化的治療策略。 PHY906 is a traditional Chinese medicine comprising four herbs that has been used for over 1800 years to alleviate various symptoms such as abdominal cramps, fever, headache, vomiting, thirst, and diarrhea. Recent studies have shown that it also has the potential to enhance the antitumor effects of a variety of chemotherapeutic and targeting agents, indicating its potential in cancer treatment. In a previous U.S. phase I/II clinical trial, patients with advanced hepatocellular cancer who received PHY906 in combination with capecitabine experienced favorable clinical outcomes. These promising findings highlight the potential of PHY906 as an effective adjunct therapy for HCC. To further investigate the efficacy of PHY906, our Phase II clinical trial involving HCC patients in Taiwan aims to validate these previous findings. By evaluating the effects of PHY906 in a larger cohort of patients, we can gain a more comprehensive understanding of its potential therapeutic value in HCC treatment. The results of this study may contribute to the development of more effective and personalized treatment strategies for patients with HCC, as well as other types of cancer.
描述:	博士指導教授:施景文委員:施景文委員:閻雲委員:吳天元委員:曾若嘉委員:李崑豪
資料類型:	thesis
顯示於類別:	[癌症生物學與藥物研發博士學位學程] 博碩士論文

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