Effects of SW20.1 on suppressing Adipogenesis in 3T3- L1 Adipocytes via the ATF3-Resistin Pathway and attenuating obesity-induced metabolic dysfunction in High Fat diet-induced Obese Mice

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Taipei Medical University Institutional Repository > 醫學院 > 國際醫學研究碩博士學位學程 > 博碩士論文 > Item 987654321/63195

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題名:	Effects of SW20.1 on suppressing Adipogenesis in 3T3- L1 Adipocytes via the ATF3-Resistin Pathway and attenuating obesity-induced metabolic dysfunction in High Fat diet-induced Obese Mice
作者:	TU, TRAN TUAN
貢獻者:	國際醫學研究博士學位學程陳錫賢林恒
關鍵詞:	SW20.1;activating transcription factor 3;obesity;resistin
日期:	2023-06-15
上傳時間:	2023-12-07 09:56:16 (UTC+8)
摘要:	Obesity has become an emerging problem globally because of its increasing prevalence. Obesity is associated with many diseases, such as cardiovascular disease, dyslipidemia, and cancer. Thus, effective new anti- obesity drugs should be urgently developed. We synthesized SW20.1, a single compound that can induce activating transcription factor 3(ATF3) expression. The results of Oil-red O staining and quantitative real-time polymerase chain reaction revealed that SW20.1 was more effective in reducing lipid accumulation in 3T3-L1 preadipocytes than the previously synthesized ST32db, and that it inhibited the expression of genes involved in adipogenesis and lipogenesis. The chromatin immunoprecipitation assay indicated that SW20.1 inhibited adipogenesis/lipogenesis by binding to the upstream promoter region of resistin at two sites (?2861/?2854 and ?241/?234). In mice, the intraperitoneal administration of SW20.1 reduced body weight, white adipocyte weight in different regions, serum cholesterol levels, adipogenesis-related gene expression, hepatic-steatosis, and serum resistin levels. Overall, SW20.1 has an anti-obesity effect by inhibiting resistin via the ATF3 pathway. Our study results indicated that SW20.1 is a promising therapeutic drug for diet-induced obesity.
描述:	博士指導教授:陳錫賢共同指導教授:林恒委員:劉典謨委員:洪欣儀委員:李文山委員:陳錫賢委員:林恒
資料類型:	thesis
顯示於類別:	[國際醫學研究碩博士學位學程] 博碩士論文

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