Investigating delayed functional connectivity networks in the human brain

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Taipei Medical University Institutional Repository > 人文暨社會科學院 > 心智意識與腦科學研究所 > 博碩士論文 > Item 987654321/62924

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題名:	Investigating delayed functional connectivity networks in the human brain
作者:	MCNAMARA, BRONTE VIRGINIA
貢獻者:	心智意識與腦科學研究所碩士班 NIALL WILLIAM DUNCAN
關鍵詞:	腦 brain
日期:	2023-06-29
上傳時間:	2023-09-27 09:43:09 (UTC+8)
摘要:	MRI-based functional connectivity is a widely used method for studying the human brain that is based upon the cross-correlations between time series from different brain regions. Traditionally, this method has been based upon cross-correlations that have no time difference between the time series (i.e., zero-lag correlation). More recently, a number of factors have suggested that time delayed correlations between brain regions may be functionally meaningful. These include a growing understanding of the BOLD signal, identification of temporal structure within brain-wide activity, and the identification of intrinsic timescales in different brain regions. When trying to study these temporal features through BOLD fMRI, it is often necessary to up-sample data in order to estimate effects at a better resolution than is provided by the raw data acquisition. In theory, this upsampling of functional connectivity could be done before the correlation step in the functional connectivity calculation is done, or after. Both approaches have been used in different contexts. The purpose of this study was to see if this methodological choice influences the results obtained. To do this, we use two different resting-state datasets, one of which includes two runs from the same participants. With these datasets we investigate the reliability of lag thread and seed based functional connectivity patterns and temporal delays within subjects and across datasets. We find that up-sampling after the correlation step produces more robust results for all measures. These results provide useful methodological information for those seeking to study functional connectivity delays with BOLD fMRI.
描述:	碩士指導教授:NIALL WILLIAM DUNCAN 委員:吳昌衛委員:吳恩賜委員:NIALL WILLIAM DUNCAN
資料類型:	thesis
顯示於類別:	[心智意識與腦科學研究所] 博碩士論文

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