Taipei Medical University Institutional Repository:Item 987654321/6248
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    Title: 台灣民間肝炎藥材之開發-第三報寄生
    Authors: 張慶芳
    ZHANG, GIN-FANG
    Contributors: 藥學研究所
    Keywords: 台灣
    肝炎


    開發
    寄生
    TAIWAN
    HEPATITIS
    LIVER
    MEDICATION
    DEVELOP
    PARASITISM
    Date: 1988
    Issue Date: 2009-09-11 16:49:02 (UTC+8)
    Abstract: 常用中藥寄生,一般乃指桑寄生藥材,根據文據上之記載供藥用者均屬桑寄生科(Lo
    ranthaceae)植物之莖或小枝。主要效用為強筋骨、袪風濕、安胎、下乳、降血壓及
    利尿,民間常用於治療神經痛及肝炎。台灣產桑寄生科植物有6屬13種,市場品常
    見的有大葉桑寄生、稠櫟寄生及台灣槲寄生。由於本省市場十分混目,因此本研究首
    先採集5屬計7種之省產寄生,依寄主及產地不同,分成根、枝、葉等共53種樣品
    ,以50%酒精抽取,分別測定保肝作用、鎮痛活性比較。結果顯示,各種桑寄生科
    植物不管寄主為何,均具有鎮痛活性。在保肝方面則有顯著的不同。
    臨床常用之台灣槲寄生及大葉桑寄生之50%乙醇抽取物顯示有意義之保肝作用,因
    此本論文乃進行其化學成分研究,配合活性檢測追蹤,以期能分離出具保肝活性及鎮
    痛活性成分,以作為開發新藥及品質管制的依據。結果如下:
    一、大葉桑寄生的葉分離出四種成分:1)Methyl palmitate 2)Quercitrin 3
    )β﹣Amyrin acetate 4)β﹣Sitosteryl glycoside。
    二、台灣槲寄生分離出五成分:1)n ﹣NOnacosane 2)β﹣Amyrin acetate 3
    )Lupeol acetate 4)Fatty alcohol mixture (C24H49OH,C26H53OH,
    C22H57OH)5)Oleanolic acid。
    三、β﹣Amyrin acetate、Lupeol acetate、n ﹣Nonacosane、Fatty alcohol 及Me
    thyl palmitate為鎮痛活性有效之主成分,Oleanolic acid及β﹣Sitosteryl glyco
    side為保肝活性之有效主要成分。
    Data Type: thesis
    Appears in Collections:[School of Pharmacy] Dissertation/Thesis

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