探討天然物及其衍生物應用於保護肥胖及胰臟類澱粉堆積條件下之胰島功能

Taipei Medical University Institutional Repository > 藥學院 > 中草藥臨床藥物研發博士學位學程 > 博碩士論文 > Item 987654321/62091

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題名:	探討天然物及其衍生物應用於保護肥胖及胰臟類澱粉堆積條件下之胰島功能 The Application of Natural Products and their Derivatives to Preserve Islet Function Under Obesity and Pancreatic Amyloidosis Conditions
作者:	SATHYANARAYANA, ASHISH RAO
貢獻者:	中草藥臨床藥物研發博士學位學程劉慧康黃偉展
關鍵詞:	Application of Natural Products
日期:	2022-07-15
上傳時間:	2022-12-07 13:50:07 (UTC+8)
摘要:	Obesity and human islet amyloid polypeptide (hIAPP) increases the risk of β-cell dysfunction. Obesity and amyloidosis are known to be the hallmarks of type 2 diabetes (T2D). In this study, protective effects of 1,2,3,4,6-penta-O-galloyl-β-D-glucose (β-PGG) and Yakuchinone-B inhibitors were evaluated on obesity and amyloidosis in high fat diet (HFD) induced and hIAPP transgenic mice models respectively. To induce obesity by HFD, mice were provided with HFD for 12 weeks and β-PG administered with HFD. On the other hand, transgenic mice model was used for the treatment of hIAPP β-cell dysfunction in mice. Oral administration of compound 4g was carried out in transgenic mice model. In HFD mice it was observed β-PGG significantly reduced free fatty acids and Triglycerides in the adipose tissue. It was also seen that b-PGG attenuated the hypotrophy of adipose tissue in HFD. Furthermore, HFD had seen to lead hepatic steaotosis, β-PGG was seen to attenuate live damage. Additionally, β-PGG was seen to attenuate via increase in GLP-1 and adiponectin levels and also decrease in inflammatory markers such as nitric oxide synthase 2 (NOS-2). Pancreatic hypotrophy was also seen to reduce when treated with β-PGG when compared to the HFD mice group. Yakuchinune-B inhibitors were observed to have protective effects on hIAPP-induced β-cell toxicity. This further led to the use of compound 4g in transgenic mice model, treated for 6 weeks. Compound 4g reduced blood glucose levels compared to the transgenic mice group. In glycaemic parameters, the levels of glucose were observed to decrease in compound 4g treated mice. Insulin resistance which leads to T2D was seen to be ameliorated, this was further seen in a reduction in HOMA-IR and an increase HOMA-B values. β-cell hypertrophy caused by hIAPP in transgenic mice was attenuated when treated with compound 4g. In this study we concluded that β-PGG and compound 4g indicated a protective effect over HFD induced obesity and hIAPP transgenic mice.
描述:	博士指導教授:劉慧康共同指導教授:黃偉展委員:張嘉銓委員:蔡惠珍委員:廖志中委員:劉慧康委員:黃偉展
資料類型:	thesis
顯示於類別:	[中草藥臨床藥物研發博士學位學程] 博碩士論文

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