神經調節治療在憂鬱症動物模式中之機轉

Taipei Medical University Institutional Repository > 醫學科技學院 > 神經再生醫學博士學位學程 > 博碩士論文 > Item 987654321/61772

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題名:	神經調節治療在憂鬱症動物模式中之機轉 The Mechanism of Neuromodulation Therapy in depression animal model
作者:	李旂緯 LEE, CHI-WEI
貢獻者:	神經再生醫學博士學位學程李宜釗林惠菁葉修華
關鍵詞:	頑固型憂鬱症;前額葉皮質;Theta波經顱磁刺激;突觸可塑性;腦源性神經營養因子 treatment-resistant depression;prefrontal cortex;theta-burst stimulation;synaptic plasticity;brain derived neurotrophic factor
日期:	2022-01-07
上傳時間:	2022-08-05 10:54:20 (UTC+8)
摘要:	頑固型憂鬱症(treatment-resistant depression，TRD)是一群對於足夠劑量和療程的抗憂鬱劑治療後仍無法改善的憂鬱症病患。而先前研究指出，創傷後壓力症候群(post-traumatic stress disorder，PTSD)所伴隨的憂鬱徵狀，會展現更強的藥物阻抗性。然而針對TRD的動物模式目前仍須建立。因此，在此研究將利用不同程度的壓力探討在大鼠模式中創傷壓力所誘導的憂鬱症之效果，並嘗試建立一具有抗憂鬱藥物阻抗性的動物模式。為探討創傷壓力在大鼠模式中之效果，我們利用足部電刺激之壓力做為創傷事件。大鼠分別接受3次、6次、10次的聲音與足部電刺激的搭配，以模擬輕度、中度、重度的壓力創傷事件。此外，近期研究指出，新形的重覆透顱磁刺激(repetitive transcranial magnetic stimulation，rTMS)，theta波經顱磁刺激(theta burst stimulation，TBS)，例如間歇性theta波經顱磁刺激(intermittent theta burst stimulation，iTBS)以及持續性theta波經顱磁刺激(continuous theta burst stimulation，cTBS)，相較於傳統的rTMS施打形式，具有更快速和強力的效應。然而，目前對於iTBS與cTBS在治療TRD的機轉仍不清楚。因此，我們以足部電刺激壓力作為壓力創傷所建立之抗憂鬱劑藥物阻抗動物模式，嘗試更進一步探討iTBS與cTBS在治療TRD上機轉的異同。 Treatment-resistant depression (TRD) which is the patients with depression to fail to respond to adequate trials of antidepressants. Previous studies have demonstrated that post-traumatic stress disorder (PTSD) with comorbid depression exhibited greater treatment resistance. However, a well-established animal model of TRD is still warranted. The present study is to use the different levels of stress to investigate the effects of traumatic stress induced-depression in rat model, and aimed to development an antidepressant resistant depression animal model. To investigate the effects of traumatic stress induced-depression in rat model. Here we used the foot-shock stress be traumatic events. The rats were received 3-,6- and 10 times tone–shock pairings to mimic mild, moderate, and severe traumatic events. Moreover, recent study has shown that a new form of repetitive transcranial magnetic stimulation (rTMS), called theta-burst stimulation (TBS), such as intermittent theta-burst stimulation (iTBS) and continuous theta burst (cTBS) was found to elicit more rapid and powerful effects than traditional rTMS protocols. However, the mechanism of iTBS and cTBS for the treatment of TRD is still unclear. Hence, we applied foot-shock stress be traumatic events to developed an antidepressant (i.e., fluoxetine)-resistant depression animal model further to investigate the difference mechanism of iTBS and cTBS in treating TRD.
描述:	博士指導教授:李宜釗共同指導教授:林惠菁共同指導教授:葉修華委員:李宜釗委員:林惠菁委員:葉修華委員:李正達委員:楊世斌委員:陳景宗委員:柯瓊媛
資料類型:	thesis
顯示於類別:	[神經再生醫學博士學位學程] 博碩士論文

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