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    請使用永久網址來引用或連結此文件: http://libir.tmu.edu.tw/handle/987654321/61746


    題名: 奈米生醫可吸收陶瓷：功能性與生物相容性檢測及動物研究
    Research on Nano Biomedical Absorbable Ceramics: Functionality, Biocompatibility and Animal Study
    作者: 卓彥君
    CHOU, YEN-CHUN
    貢獻者: 牙體技術學系碩士班
    黃瓊芳
    關鍵詞: 半水硫酸钙;生物陶瓷;骨缺损;骨移植替代品;骨再生
    calcium sulfate hemihydrate;bioceramic;bone defect;bone graft substitute;bone regeneration
    日期: 2022-01-14
    上傳時間: 2022-08-01 11:45:25 (UTC+8)
    摘要: 目標：依據ISO 10993-6 規範，將奈米生醫可吸收陶瓷植入兔子腿骨，評估並比較植入奈米生醫可吸收陶瓷後新骨形成以及局部組織反應。
    研究方法：將測試物品與無菌水混合（測試物：水= 1：0.6），接著將測試物品填入植入預定位置。對照物和假手術（空白）用作本試驗中的對照組。對照物切成較小塊後再進行植入。在每個時間點 (2 週，4 週，8 週及12 週) 進行μCT分析，計算骨填充物的降解率和新生骨形成率。實驗結束後，將兔子犧牲後取其組織切片進行觀察。
    Abstract
    Title of Thesis: Research on nano biomedical absorbable ceramics: functionality, biocompatibility and animal study
    Author: Chou, Yen-Chun
    Thesis advised by: Prof. Chiung-Fang Huang, School of Dental Technology, Taipei Medical University

    The present study implanted an innovative bioceramic (α-calcium sulfate hemihydrate; α-CSH) on rabbit models' femur lateral condyle cortical bone. The local effect and micro-computed tomographic (μ-CT) assessment were conducted. The innovative α-CSH bioceramic was synthesized through a green processing technology (microwave irradiation treatment). The bilateral implantation model was performed among 24 New Zealand White rabbits divided into three groups based on the type of filling materials: α-CSH, control, and blank. Treatments were performed in defects with 6 mm diameter and 7 mm depth and observed after 2, 4, 8, and 12 weeks. The present study evaluated material reaction and bone formation after implantation radiographically and histopathologically.
    The μ-CT analysis results showed that the degradation of α-CSH and control material was similar at 4 and 8 weeks. The bone volume in the defects indicated the α-CSH increased most in 8 weeks. In histopathological evaluation, for the α-CSH group, the bone defect area filled with lamellar bone and well-grown bone marrow infiltration is similar to that of the control material.
    Moreover, the α-CSH revealed a faster degradation rate and better healing progress than the control material under the same conditions. Therefore, the α-CSH was confirmed to help promote osteoconduction and control the resorption rate in bone defects. Further, the innovative α-CSH could be considered a promising bone substitute for reconstructive bone therapy in dental and orthopedic fields.
    描述: 碩士
    指導教授:黃瓊芳
    委員:黃瓊芳
    委員:彭珮雯
    委員:藍文謙
    資料類型: thesis
    顯示於類別:[牙體技術學系] 博碩士論文

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