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    題名: (CsPb1-xSnxI3)量子點/聚苯乙烯/四甲氧基矽烷複合材料之螢光靈敏度應用於檢測 pH值與脲酶濃度變化
    The fluorescence sensitivity of quantum dots CsPb1-xSnxI3 on polystyrene/tetramethoxysilane for detecting changes in pH and urease concentration
    作者: NGUYET, NGUYEN VO THANH
    貢獻者: 奈米醫學工程研究所碩士班
    郭聰榮
    陳志華
    關鍵詞: Perovskite quantum dots;Polystyrene/tetramethoxysilane;Biosensor;pH sensing;Urease detector
    日期: 2021-07-02
    上傳時間: 2022-01-05
    摘要: CsPbI3 NCs are promising candidates for optoelectronics, bioimaging, and biosensor application due to their high quantum yield, size-controllable emission wavelength, and defect tolerance. However, an unstable crystal phase of CsPbI3 when contacted to ambient air limited their bioapplication. To claim these limitations, Sn is alloyed with Pb in the CsPbI3 lattice by hot injection preparation to produce CsPb1-xSnxI3 QDs with higher emission intensity and stability than pure CsPbI3 QDs. After two months, CsPb1-xSnxI3 QDs maintain 91.6% of their initial PL intensity. These CsPb0.4Sn0.6I3 QDs are modified surface ligand by AET and then coated with polystyrene-SiO2, generating PPSM composite with double core-shells that are stable in water and can be used as pH and urease sensors. After 1 hour in aqueous solution, PPSM microspheres can maintain 54.6 % of their original fluorescence intensity and showed sensitivity in the pH range of 5 to 9. The mechanism of urease sensing system is based on rapid urease test use to detect Helicobacter pylori bacteria in patients with peptic ulcer disease. The PL intensity data show the linear relationship between PPSM quenched and urease concentration. The result showed that in the range of urease concentration from 0.2 to 1.0 U/mL, the PL intensity of the PPSM decreased as the urease concentration increased. These findings suggest PPSM can be used as pH and urease sensing to detect some diseases in human body and expand the application of CsPbI3-based nanocrystals in biomedical.
    描述: 碩士
    指導教授:郭聰榮
    指導教授:陳志華
    委員:曾靖孋
    委員:楊正昌
    委員:林群哲
    資料類型: thesis
    顯示於類別:[奈米醫學工程研究所] 博碩士論文

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